This double-blind placebo-controlled study (n=25) assessed the effects of LSD on metabolic pathways associated with neural plasticity, to gain insight into the relationship between neural plasticity, ageing and LSD-induced cognitive gains in both humans and rodents. LSD treatment in humans (50μg) enhanced performance in a visuospatial memory task, and in a novel object recognition task in rodents indicating that LSD has nootropic effects.
- Published
- Journal
- Experimental Neurology
- Authors
- Cini, F. A., Costa, M. N., de Araujo, D. B., Falchi, M., Feilding, A., Goto-Silva, L., Marcos, E., Martins-de-Souza, D., Nascimento, J. M., Olivieri, R., Ornelas, I. M., Palhano-Fontes, F., Rehen, S. K., Renno-Costa, C., Ribeiro, S., Sequerra, E., Silva, S. R. B., Tófoli, L.F., Wießner, I.