In a small open‑label trial of 10 patients with chronic cluster headache, three oral doses of psilocybin (0.14 mg/kg) were well tolerated and produced a mean 31 per cent reduction in attack frequency, with one patient achieving 21 weeks' remission. Changes in hypothalamic–diencephalic functional connectivity on fMRI correlated strongly with attack reduction (R = −0.81), implicating hypothalamic circuits in the therapeutic response and supporting further clinical study.
- Published
- Journal
- Headache
- Authors
- Madsen, M. K., Petersen, A. S., Stenbæk, D. S., Sørensen, I. M., Schiønning, H., Fjeld, T., Nykjær, C. H., Larsen, S. M. U., Grzywacz, M., Mathiesen, T., Klausen, I. L., Overgaard‐Hansen, O., Brendstrup‐Brix, K., Linnet, K., Johansen, S. S., Fisher, P. M., Jensen, R. H., Knudsen, G. M.