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Human Brain Mapping

9 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Investigating Emotional Reactivity in Experienced Users of Psychedelics: a cross-sectional fMRI study

In a preregistered cross-sectional fMRI study comparing experienced naturalistic psychedelic users (≥10 lifetime uses; N = 33) with matched non‑users (N = 34), users were faster and more accurate at recognising angry faces, suggesting reduced interference from threat-related stimuli. Neuroimaging showed diminished limbic and salience‑network responses to anger, enhanced parietal and sensorimotor responses to happiness, increased precuneus activation to fear, and reduced emotional‑category differentiation in the frontal medial cortex and parahippocampal gyrus, indicating sustained neurofunctional alterations in emotional processing associated with naturalistic psychedelic use.

Published
Journal
Human Brain Mapping
Authors
Orłowski, P., Domagalik, A., Bola, M.
Open Accessindividual

The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State

Using fMRI and MEG in healthy volunteers during acute LSD, the study shows that DLPFC functional connectivity—notably bilateral DLPFC–thalamus–FFA coupling—correlates with subjective ego dissolution, while right DLPFC–IPS–salience network coupling correlates with emotional arousal. MEG Granger causality further revealed increased theta‑band information flow between thalamus and DLPFC, consistent with disrupted thalamic gating during ego dissolution.

Published
Journal
Human Brain Mapping
Authors
Coleman, J. A., Shinozuka, K., Tromm, R., Dipasquale, O., Kaelen, M., Roseman, L., Muthukumaraswamy, S., Nutt, D. J., Barnett, L., Carhart-Harris, R. L.
Open Accessindividual

P300-mediated modulations in self-other processing under psychedelic psilocybin are related to connectedness and changed meaning: A window into the self-other overlap

In a placebo‑controlled, double‑blind crossover EEG study (n = 17), psilocybin abolished the P300‑timeframe distinction between self‑ and other‑related auditory feedback—driven by current source density changes in the supragenual anterior cingulate and right insula—and the magnitude of this effect correlated with subjective feelings of unity and changed meaning. These findings indicate 5‑HT‑mediated modulation of late self‑referential encoding underlies altered self–other overlap and may inform therapeutic models emphasising connectedness.

Published
Journal
Human Brain Mapping
Authors
Smigielski, L., Kometer, M., Scheidegger, M., Stress, C., Preller, K. H., Koenig, T., Vollenweider, F. X.
Open Accessindividual

Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study

In 159 healthy volunteers, PET imaging with [18F]altanserin and [11C]Cimbi‑36 showed no significant association between neocortical 5‑HT2A receptor availability and trait Openness (NEO‑PI‑R), and no sex interactions. Thus baseline 5‑HT2A binding does not appear to account for individual differences in Openness despite evidence that 5‑HT2A agonists such as psilocybin can increase the trait.

Published
Journal
Human Brain Mapping
Authors
Stenbæk, D. S., Kristiansen, S., Burmester, D., Madsen, M. K., Frokjaer, V. G., Knudsen, G. M., Fisher, P. M.
Open Accessindividual

LSD-induced entropic brain activity predicts subsequent personality change

In a placebo‐controlled resting‑state fMRI study, intravenous LSD robustly increased sample entropy across sensory and higher‑order brain networks. These LSD‑induced entropy increases—most predictive during music listening and when ego‑dissolution was reported—forecasted enduring increases in the personality trait openness at a two‑week follow‑up.

Published
Journal
Human Brain Mapping
Authors
Lebedev, A. V., Kaelen, M., L€ Ovd En, M., Nilsson, J., Feilding, A., Nutt, D. J., Carhart-Harris, R. L.
Open Accessindividual

LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion

Using resting-state fMRI with retinotopic localisers, the study found that LSD increases functional connectivity between retinotopically congruent patches of early visual cortex (V1–V3) during eyes-closed rest compared with placebo. This suggests that under LSD the early visual system behaves as if receiving spatially localised visual input, consistent with eyes‑closed psychedelic imagery.

Published
Journal
Human Brain Mapping
Authors
Roseman, L., Sereno, M. I., Leech, R., Kaelen, M., Orban, C., Mcgonigle, J., Feilding, A., Nutt, D. J., Carhart-Harris, R. L.

Quick Facts

Papers Indexed
9
h-Index
225
Open Access
Yes
Publisher
Wiley
Country
United States
Website
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