Using fMRI and MEG in healthy volunteers during acute LSD, the study shows that DLPFC functional connectivity—notably bilateral DLPFC–thalamus–FFA coupling—correlates with subjective ego dissolution, while right DLPFC–IPS–salience network coupling correlates with emotional arousal. MEG Granger causality further revealed increased theta‑band information flow between thalamus and DLPFC, consistent with disrupted thalamic gating during ego dissolution.
- Published
- Journal
- Human Brain Mapping
- Authors
- Coleman, J. A., Shinozuka, K., Tromm, R., Dipasquale, O., Kaelen, M., Roseman, L., Muthukumaraswamy, S., Nutt, D. J., Barnett, L., Carhart-Harris, R. L.