In a randomised, double‑blind trial of single subanaesthetic infusions of racemic ketamine or esketamine in 61 people with treatment‑resistant major depressive disorder, higher baseline illness severity and a greater number of prior treatment failures predicted poorer outcomes. Specifically, more treatment failures and greater severity were associated with lower odds of remission at 7 days and reduced likelihood of response at 24 hours.
- Published
- Journal
- Human Psychopharmacology
- Authors
- Bandeira, I. D., Caliman-Fontes, A. T., Correia-Melo, F. S., Echegaray, M. VF., Guerreiro-Costa, L. N. F., Jesus-Nunes, A. P., Kapczinski, F., Lacerda, A. L. T., Leal, G. C., Machado-Vieira, R., Marback, R. F., Mello, R. P., Quarantini, L. C., Santos-Lima, C., Souza-Marques, B.