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Academic Journal

Journal of Cerebral Blood Flow and Metabolism

2 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach

This brain imaging study (n=11) found that a single intravenous dose of ketamine (70mg/70kg) increased glutamate levels in the anterior cingulate cortex and altered functional connectivity between this region, the dlPFC, and the amygdala in healthy men. Multimodal imaging also suggested that ketamine-related increases in a putative marker of synaptic plasticity were linked to reduced default mode network activity.

Published
Journal
Journal of Cerebral Blood Flow and Metabolism
Authors
Agnorelli, C., Peill, J., Sawicka, G., Kurtin, D., Shatalina, E., Ahmad, K., Wall, M. B., Rua, C., Godfrey, K., Ertl, N., Searle, G., Zhou, K., Osugo, M., Weiss, B., Greenway, K. T., Fagiolini, A., Carhart-Harris, R., Matthews, P. M., Rabiner, E. A., Nutt, D., Erritzoe, D.
Open Accessindividual

Acute psilocybin and ketanserin effects on cerebral blood flow: 5-HT2AR neuromodulation in healthy humans

In a single‑blind cross‑over study of 28 healthy volunteers, acute psilocybin — but not the 5‑HT2A antagonist ketanserin — produced significant global and regional reductions in cerebral blood flow that correlated with plasma psilocin and subjective drug intensity (approximately 11.6% at peak). Psilocybin also caused a 10.5% constriction of the internal carotid artery, providing the first in vivo human evidence of asymmetric 5‑HT2A receptor modulation of cerebral haemodynamics.

Published
Journal
Journal of Cerebral Blood Flow and Metabolism
Authors
Larsen, K., Lindberg, U., Ozenne, B., McCulloch, D. E-W., Armand, S., Madsen, M. K., Johansen, A., Stenbæk, D. S., Knudsen, G. M., Fisher, P. M.

Quick Facts

Papers Indexed
2
h-Index
222
Open Access
No
Publisher
SAGE Publications
Country
United States
Website
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