This brain imaging study (n=11) found that a single intravenous dose of ketamine (70mg/70kg) increased glutamate levels in the anterior cingulate cortex and altered functional connectivity between this region, the dlPFC, and the amygdala in healthy men. Multimodal imaging also suggested that ketamine-related increases in a putative marker of synaptic plasticity were linked to reduced default mode network activity.
- Published
- Journal
- Journal of Cerebral Blood Flow and Metabolism
- Authors
- Agnorelli, C., Peill, J., Sawicka, G., Kurtin, D., Shatalina, E., Ahmad, K., Wall, M. B., Rua, C., Godfrey, K., Ertl, N., Searle, G., Zhou, K., Osugo, M., Weiss, B., Greenway, K. T., Fagiolini, A., Carhart-Harris, R., Matthews, P. M., Rabiner, E. A., Nutt, D., Erritzoe, D.