In the first qualitative study embedded in a randomised, placebo‑controlled trial, interviews with 40 healthy males who microdosed 10 µg LSD every third day for six weeks identified effects across mood, social life, mindfulness, cognition/creativity and physiology, with overarching themes of increased openness and bidirectional (positive and negative) effects. These findings highlight clinically relevant signals (notably changes in anxiety) that bear on patient and dose selection for mood‑disorder trials and emphasise set, setting and placebo‑related uncertainty as key considerations for psychedelic trial design.
- Published
- Journal
- Journal of Humanistic Psychology
- Authors
- Murphy, R. J., Wardlaw, M., Smith, T., Noorani, T., Evans, W., Reynolds, L., Menkes, D. B., Sumner, R. L., Muthukumaraswamy, S. D.