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Journal of Neuroscience

5 Papers Indexed in Blossom

Published Papers

Open Accessindividual

DMT-induced shifts in criticality correlate with self-dissolution

DMT shifts brain oscillatory dynamics away from criticality—towards subcritical regimes—in alpha and adjacent (theta) bands, increasing entropy and reducing complexity. These shifts, quantified via a functional excitatory–inhibitory ratio, correlate with the intensity of subjective self‑dissolution.

Published
Journal
Journal of Neuroscience
Authors
Irrmischer, M., Aqil, M., Luan, L., Wang, T., Engelbregt, H., Carhart-Harris, R., Linkenkaer-Hansen, K., Timmermann, C.
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Beyond the 5-HT2A Receptor: Classic and Nonclassic Targets in Psychedelic Drug Action

This mini‑review argues that 5‑HT2A activation is only one facet of serotonergic psychedelic action, which also involves other serotonin receptors (5‑HT1A, 5‑HT2C), neurotrophin receptors (e.g. TrkB), promotion of neuroplasticity and possible protein post‑translational modifications. It highlights efforts to develop non‑hallucinogenic derivatives that retain therapeutic neuroplastic effects while minimising the intense psychedelic experience.

Published
Journal
Journal of Neuroscience
Authors
Cameron, L. P., Benetatos, J., Lewis, V., Bonniwell, E. M., Jaster, A. M., Moliner, R., Castrén, E., Mccorvy, J. D., Palner, M., Aguilar-Valles, A.
Open Accessmeta

Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine

This review summarises preclinical and clinical evidence that ketamine, psilocybin, LSD and MDMA have therapeutic potential for psychiatric disorders — with robust support for ketamine in depression, emerging evidence for psilocybin and LSD in treating depression and modulating functional brain connectivity, and MDMA showing efficacy in PTSD. It also delineates the pharmacology and behavioural effects of psychedelic versus non‑psychedelic hallucinogens and entactogens.

Published
Journal
Journal of Neuroscience
Authors
Hibicke, M., Gobbi, G.
Open Accessindividual

Role of the 5-HT2A Receptor in Self- and Other-Initiated Social Interaction in Lysergic Acid Diethylamide-Induced States: A Pharmacological fMRI Study

In a double-blind, placebo-controlled fMRI study with eye-tracking, LSD reduced activity in brain regions supporting self-processing and social cognition and diminished the efficiency of establishing joint attention; these effects were abolished by the 5‑HT2A antagonist ketanserin. The findings implicate 5‑HT2A receptor stimulation as the mechanism underlying LSD’s sociocognitive effects and point to the 5‑HT2A system as a potential treatment target for social impairments in psychiatric disorders.

Published
Journal
Journal of Neuroscience
Authors
Preller, K. H., Schilbach, L., Pokorny, T., Flemming, J., Seifritz, E., Vollenweider, F. X.
Open Accessindividual

Broadband Cortical Desynchronization Underlies the Human Psychedelic State

Using MEG in healthy volunteers after intravenous psilocybin, the study shows broadband reductions in spontaneous cortical oscillatory power—especially in posterior association cortices and default‑mode network regions—while visually and motor‑induced gamma oscillations were preserved. Dynamic causal modelling indicates this desynchronisation is likely driven by 5‑HT2A‑mediated excitation of deep‑layer pyramidal neurons (notably in posterior cingulate cortex), linking cortical desynchronisation to the psychedelic state.

Published
Journal
Journal of Neuroscience
Authors
Muthukumaraswamy, S. D., Carhart-Harris, R. L., Moran, R. J., Brookes, M. J., Williams, T. M., Errtizoe, D., Sessa, B., Papadopoulos, A., Bolstridge, M., Singh, K. D., Feilding, A., Friston, K. J., Nutt, D. J.

Quick Facts

Papers Indexed
5
h-Index
515
Open Access
No
Publisher
Society for Neuroscience
Country
United States
Website
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