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Academic Journal

Journal of Pharmacology and Experimental Therapeutics

3 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Novel Benzofuran Derivatives Induce Monoamine Release and Substitute for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine

This in vitro and in vivo study investigates novel analogues of the designer drug 5-(2-methylaminopropyl) benzofuran (5-MAPB) as potential MDMA-like monoamine releasers. The research reveals that the S isomers of 5- and 6-(2-methylaminobutyl)benzofuran (5-MABB and 6-MABB) exhibit efficacy as releasing agents for serotonin, norepinephrine, and dopamine transporters. In contrast, the R isomers show reduced potency in inducing behavioural effects, suggesting the aminoalkyl benzofuran scaffold is a potential template for developing compounds with MDMA-like properties.

Published
Journal
Journal of Pharmacology and Experimental Therapeutics
Authors
Johnson, C. B., Walther, D., Baggot, M. J., Baker, L. E., Baumann, M. H.
Paywallindividual

Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT) 2A and 5-HT2C receptors

This comparative study on 2,5-Dimethoxy-4-substituted phenylisopropylamines and phenethylamines examines their activity as serotonin 5-HT2A/2C agonists. It finds that phenylisopropylamines generally exhibit higher efficacy than phenethylamines at the 5-HT2A receptor, but both act as partial agonists at the 5-HT2C receptor. The research highlights differential activation of phospholipase C (PLC) and phospholipase A2 (PLA2) pathways by these compounds in cell-based assays, with phenylisopropylamines showing stronger efficacy as head shake inducers in rats, supporting the concept of functional selectivity in receptor signaling pathways.

Published
Journal
Journal of Pharmacology and Experimental Therapeutics
Authors
Moya, P. R., Berg, K. A., Gutiérrez-Hernandez, M. A., Sáez-Briones, P., Reyes-Parada, M., Cassels, B. K., Clarke, W. P.
Open Accessindividual

Human pharmacology of ayahuasca: subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics

This double-blind, placebo-controlled clinical study (n=18) investigated the subjective and cardiovascular effects and alkaloid pharmacokinetic properties of orally ingested ayahuasca (42-60mg DMT/70kg) in healthy volunteers. The time course of DMT plasma concentrations closely paralleled subjective effects. The pharmacokinetic results indicated a predominantly harmine-DMT interaction in the gastrointestinal tract and possibly in the liver.

Published
Journal
Journal of Pharmacology and Experimental Therapeutics
Authors
Riba, J., Valle, M., Urbano, G., Yritia, M., Morte, A., Dјinvestigacio ´farmacolo, R.

Quick Facts

Papers Indexed
3
h-Index
250
Open Access
No
Publisher
Elsevier
Country
United States
Website
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