Using a novel turbulence framework that quantifies vorticity (local synchrony) and extends metastability to space and time, the study shows that LSD and psilocybin produce consistent yet discriminable compression of the brain’s functional hierarchy, most notably altering the default mode network. These results quantify how two psychedelics modulate hierarchical brain dynamics and support their proposed mechanistic role relevant to therapeutic applications.
- Published
- Journal
- Network Neuroscience
- Authors
- Cruzat, J., Perl, Y. S., Escrichs, A., Vohryzek, J., Timmermann, C., Roseman, L., Luppi, A. I., Ibañez, A., Nutt, D. J., Carhart-Harris, R. L., Tagliazucchi, E., Deco, G., Kringelbach, M. L.