Neurobiology of Disease

Ketamine accelerates fear extinction via mTORC1 signaling

This rat study explores the mechanisms underlying the actions of ketamine in fear conditioning, extinction, and renewal. The study found that ketamine produces long-lasting positive changes in fear extinction, through mTORC1/protein synthesis in the medial prefrontal cortex. This offers more evidence for why and how ketamine may be a potential approach for the treatment of PTSD.

Published

April 1, 2017

Journal

Neurobiology of Disease

Authors

Girgenti, M. J., Ghosal, S., Lopresto, D., Taylor, J. R., Duman, R. S., Ribicoff, A.