This rat study explores the mechanisms underlying the actions of ketamine in fear conditioning, extinction, and renewal. The study found that ketamine produces long-lasting positive changes in fear extinction, through mTORC1/protein synthesis in the medial prefrontal cortex. This offers more evidence for why and how ketamine may be a potential approach for the treatment of PTSD.
- Published
- Journal
- Neurobiology of Disease
- Authors
- Girgenti, M. J., Ghosal, S., Lopresto, D., Taylor, J. R., Duman, R. S., Ribicoff, A.