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npj Mental Health Research

2 Papers Indexed in Blossom

Published Papers

Open Accessindividual

A qualitative analysis of the psychedelic mushroom come-up and come-down

This qualitative analysis of Erowid.org experience reports (n=279) examines the temporal structure (organisation of time) of psilocybin experiences, focusing on the 'come-up' and 'come-down' phases. The study finds that the onset phase typically resembles an acute stress reaction with negative feelings. In contrast, the descending phase is characterised by positive feelings similar to post-stress recovery, suggesting a potentially important therapeutic mechanism.

Published
Journal
npj Mental Health Research
Authors
Brouwer, A., Brown, J., Erowid, E., Erowid, F., Raison, C. L., Carhart-Harris, R. L.
Open Accessmeta

Meta-correlation of the effect of ketamine and psilocybin induced subjective effects on therapeutic outcome

This meta-analysis (2024, s=31) examines the correlation between subjective effects and therapeutic outcomes for ketamine (s=23, n=471) and psilocybin (s=8, n=183) in depression and substance use disorder (SUD) treatment. It finds modest mediating effects of subjective experiences on therapeutic outcomes, with psilocybin showing a stronger mediating effect (R² = 24%) compared to ketamine (R² = 5-10%), and a greater mediating effect observed in SUD compared to depression regardless of the substance used.

Published
Journal
npj Mental Health Research
Authors
Dahan, J. D. C., Dadiomov, D., Bostoen, T., Dahan, A.

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Papers Indexed
2
Publisher
Nature Portfolio
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