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2 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Plasma BDNF concentrations and the antidepressant effects of six ketamine infusions in unipolar and bipolar depression

This open-label study (n=94) finds that baseline plasma BDNF concentrations (a protein related to nerve growth) correlate with ketamine (6 infusions, 35mg/70kg) antidepressant effects (MADRS).

Published
Journal
PeerJ
Authors
Zheng, W., Zhou, Y. L., Wang, C. Y., Lan, X. F., Zhang, B., Zhou, S. M., Yan, S., Ning, Y. P.
Open Accessindividual

Harmine stimulates proliferation of human neural progenitors

Harmine markedly increases proliferation of human neural progenitor cells (hNPCs) derived from pluripotent stem cells, enlarging the proliferating pool by 71.5% after four days in vitro. The proliferation was mimicked by the DYRK1A inhibitor INDY but not by the MAO inhibitor pargyline, implicating DYRK1A inhibition as a likely mechanism and potentially explaining harmine’s antidepressant effects.

Published
Journal
PeerJ
Authors
Dakic, V., De Moraes Maciel, R., Drummond, H., Nascimento, J. M., Trindade, P., Rehen, S. K.

Quick Facts

Papers Indexed
2
h-Index
124
Open Access
Yes
Publisher
Taylor & Francis
Country
United States
Website
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