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3 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Safety Profile and Suicidality Associated with the Use of Esketamine in the Treatment of Major Depressive Disorder in European Countries: An EudraVigilance Database Analysis

This pharmacovigilance analysis (n=751) examines suspected adverse reactions (SARs) to esketamine nasal spray (Spravato) reported in the EudraVigilance database across European countries. The study identifies increased blood pressure (15.4%) and dissociation (15%) as the most common SARs, with data suggesting a potentially higher risk of suicidality with esketamine compared to fluoxetine and venlafaxine, prompting recommendations for careful monitoring of patients with a history of suicidal ideation.

Published
Journal
Pharmaceuticals
Authors
Ammendolia, I., Mannucci, C., Esposito, E., Calapai, G., Currò, M., Midiri, P., Mondello, C., Cardia, L., Calapai, F.
Open Accessmeta

Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors

This review (2021) presents a framework to understand the basis for using psilocybin to treat individuals with suicidal behaviours. The positive effects psilocybin has on suicidal behaviours are discussed, specifically its role as a 5-HT2A receptor agonist and its ability to increase neuroplasticity and suppress inflammation.

Published
Journal
Pharmaceuticals
Authors
Strumila, R., Guillaume, S.
Open Accessindividual

The Impact of Childhood Maltreatment on Intravenous Ketamine Outcomes for Adult Patients with Treatment-Resistant Depression

In adults with treatment-resistant depression receiving intravenous ketamine, clinically significant childhood sexual and physical abuse and greater cumulative maltreatment predicted larger reductions in depressive symptoms after single and repeated infusions and higher remission rates after repeated treatment. This suggests ketamine may be especially effective in TRD patients with high childhood trauma burden, perhaps by blocking trauma-associated behavioural sensitisation, in contrast to poorer responses seen with conventional antidepressants.

Published
Journal
Pharmaceuticals
Authors
O'brien, B., Lijffijt, M., Wells, A., Swann, A. C., Mathew, S. J.

Quick Facts

Papers Indexed
3
h-Index
103
Open Access
Yes
Publisher
MDPI
Country
Switzerland
Website
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