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Pharmacology Biochemistry and Behavior

5 Papers Indexed in Blossom

Published Papers

Paywallindividual

Serotonin antagonists fail to alter MDMA self-administration in rats

This vehicle-controlled rat study (n=23) investigated the role of serotonergic agonists in preventing relapse into drug-seeking behavior, in response to re-exposure to a single dose of MDMA or cocaine (10.0 mg/kg), or a conditioned light-cue associated with their drug-intake prior to extinction. Results indicate that 5-HT1A and 5-HT2A agonists prevent relapse into cocaine self-administration, but neither of the 5-HT1A, 5-HT1B, or 5-HT2A agonists could alter the maintenance of MDMA self-administration. However, the 5-HT1A agonists prevented relapse into drug-seeking behavior elicited by exposure to cues that had been associated with self-administered MDMA.

Published
Journal
Pharmacology Biochemistry and Behavior
Authors
Schenk, S., Foote, J., Aronsen, D., Bukholt, N., Highgate, Q., Van De Wetering, R., Webster, J.
Open Accessindividual

Behavioral and pharmacokinetic interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-NN-dimethyltryptamine

This rat study (n=180) investigated the pharmacokinetic interactions between 5-MeO-DMT (0.25mg/0.25kg) and the MAO-A inhibitor clorgyline and the MAO-A/B inhibitor pargyline, and their effects on prepulse inhibition (PPI), a phenomenon related to the ability to filter out unnecessary information. Results confirmed that the MAO inhibitors increase the accumulation of 5-MeO-DMT in the nervous system, and boost its disruptive effects on PPI by activating the 5-HT2a receptor pathway.

Published
Journal
Pharmacology Biochemistry and Behavior
Authors
Halberstadt, A. L.
Open Accessindividual

MDMA decreases the effects of simulated social rejection

This placebo-controlled study (n=36) investigated the effects of MDMA (52.5mg & 105mg/70kg) on social rejection, as measured by self-reported ratings of positive mood and self-esteem in response to being excluded during a virtual ball-toss game. MDMA increased subjective pro-social feelings of lovingness, and reduced the impact of simulated social rejection on mood and self-esteem, in a dose-dependent manner.

Published
Journal
Pharmacology Biochemistry and Behavior
Authors
Frye, C. G., Wardle, M. C., Norman, G. J., De Wit, H.
Paywallindividual

R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine

This vehicle-controlled mouse study (n=40) compared the antidepressant efficacy between R(-) and S(+) isomer forms of ketamine (10mg/kg) and found that both forms produce rapid antidepressant effects, but only arketamine produces long-lasting antidepressant effects persisting 7 days after a single infusion.

Published
Journal
Pharmacology Biochemistry and Behavior
Authors
Zhang, J., Hashimoto, K., Li, S.
Paywallindividual

Activities of extract and constituents of Banisteriopsis caapi relevant to parkinsonism

This early cell-based study (2003) found that B. caapi stem extract may be useful in the treatment of Parkinson's disease. This study was the first to find it stimulated dopamine release.

Published
Journal
Pharmacology Biochemistry and Behavior
Authors
Schwarz, M. J., Houghton, P. J., Rose, S., Jenner, P., Lees, A. D.

Quick Facts

Papers Indexed
5
h-Index
150
Open Access
No
Publisher
Elsevier
Country
United States
Website
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