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Progress in Neuro-Psychopharmacology and Biological Psychiatry

12 Papers Indexed in Blossom

Published Papers

Open Accessindividual

LSD microdosing for major depressive disorder: Mood and pharmacokinetic outcomes from a Phase 2a trial

This open-label trial (n=19) found that repeated microdosed LSD (8 to 20 μg) was associated with short-term improvements in daily mood, but not same-day changes in self-reported depression, in people with major depressive disorder. It also provided pharmacokinetic data for sublingual LSD and found no evidence of tolerance or sensitisation across the 8-week dosing regimen.

Published
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Authors
Daldegan-Bueno, D., Donegan, C. J., Sumner, R., Forsyth, A., Jeong, S. H., Evans, W., Alshakhouri, M., Murphy, R. J., Reynolds, L., Hoeh, N., Allen, N., Sundram, F., Menkes, D. B., Muthukumaraswamy, S.
Open Accessindividual

Cognitive outcomes following psilocybin-assisted therapy in treatment-resistant depression: A post-hoc analysis of a randomized, waitlist-controlled trial

This secondary analysis (n=26) of adults with treatment-resistant depression from an open-label psilocybin-assisted psychotherapy trial found statistically significant improvements in processing speed and executive function at two weeks post-treatment, with gains on Trail Making Tests remaining significant after adjusting for depressive symptoms; however, reliable change indices showed that the proportion of participants achieving meaningful improvement (4.2–12.5%) did not exceed chance expectations, suggesting observed gains may reflect practice effects rather than genuine procognitive benefits.

Published
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Authors
Johnson, D. E., Meshkat, S., Kaczmarek, E. S., Rabin, J. S., Brudner, R. M., Chisamore, N., Doyle, Z., Bawks, J., Riva-Cambrin, J., Mansur, R. B., Lipsitz, O., McIntyre, R. S., Lanctôt, K. L., Rosenblat, J. D.
Open Accessindividual

Processing of self-related thoughts in experienced users of classic psychedelics and non-users: a source localisation EEG study

This comparative study (dataset I: n=70, II: n=38) explores differences between naturalistic psychedelics users and non-users during the processing of self-related thoughts, using behavioural testing combined with EEG and source localization. Results from Dataset I suggest weaker increases in alpha and beta power in psychedelics users, primarily in brain regions linked to processing self-related information and memory. However, Dataset II did not replicate these effects, possibly due to sample size and spatial resolution limitations.

Published
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Authors
Ruban, A., Magnuski, M., Hobot, J., Orłowski, P., Kołodziej, A., Bola, M., Brzezicka, A.
Open Accessmeta

MDMA-assisted psychotherapy for PTSD: Growing evidence for memory effects mediating treatment efficacy

This review (2023) explores the potential mechanisms behind the efficacy of MDMA-assisted psychotherapy for posttraumatic stress disorder (PTSD). The article examines recent preclinical and clinical evidence, focusing on MDMA's mnemonic (memory) effects, its impact on fear extinction and reconsolidation, and its relevance for PTSD treatment.

Published
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Authors
Sarmanlu, M., Kuypers, K. P. C., Vizeli, P., Kvamme, T. L.
Paywallmeta

Acute effects of ketamine and esketamine on cognition in healthy subjects: A meta-analysis

This meta-analysis assessed the effects of ketamine administration in healthy participants (n=1,041) on several cognitive domains. Deficits in verbal learning/memory were most prominent, whereas response inhibition was the least affected. Negative effects were dependent on infusion dose and plasma level but unaffected by enantiomer type, route of administration, sex or age.

Published
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Authors
Zhornitsky, S., Pelletier, R., Assaf, R., Potvin, S., Li, C-S., Tourjaman, V.
Paywallmeta

Efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for posttraumatic stress disorder: A systematic review and meta-analysis.

This systematic review and meta-analysis (2020) found 5 trials (n=106) that found large reductions in PTSD symptoms after MDMA-assisted psychotherapy. The studies showed large improvements, but were only moderate in quality.

Published
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Authors
Bahji, A., Forsyth, A., Groll, D., Hawken, E. R., Pgy5

Quick Facts

Papers Indexed
12
h-Index
157
Open Access
No
Publisher
Elsevier
Country
United States
Website
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