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2 Papers Indexed in Blossom

Published Papers

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Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism

This rat study demonstrated a causal link between reduced prefrontal mGluR2 receptor function and both impaired executive control and alcohol craving. It finds that psilocybin restored mGluR2 expression and reduced alcohol relapse behaviour, identifying a potential biomarker strategy for treating alcohol dependence.

Published
Journal
Science Advances
Authors
Barroso Flores, J., Hoffmann, R., Wagner, K., Neumaier, B., Bartsch, D., Spanagel, R., Sommer, W. H.
Open Accessindividual

Trips and Neurotransmitters: Discovering Principled Patterns across 6,850 Hallucinogenic Experiences

Analysing 6,850 free-form testimonials across 27 hallucinogens with 40 neurotransmitter receptor proxies mapped to brain coordinates, the study uses pattern-learning to link distinct subjective experience themes to cortex-wide receptor density distributions. It finds that ego-dissolution relates to a 5-HT2A, D2, KOR and NMDA receptor constellation anchored in higher-order associative and visual cortices, and more broadly identifies association–sensory gradients that map the semantic structure of psychedelic experiences onto brain receptor architecture with potential therapeutic implications.

Published
Journal
Science Advances
Authors
Ballentine, G., Friedman, S. F., Bzdok, D.

Quick Facts

Papers Indexed
2
h-Index
288
Open Access
Yes
Publisher
American Association for the Advancement of Science
Country
United States
Website
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