This randomised, cross-over study (n=7) used precision functional mapping with high-resolution multi-echo fMRI to characterise psilocybin (25mg) versus methylphenidate effects on brain networks, revealing decreased network modularity during psilocybin exposure and reproducible network changes. Participants showed unique brain configurations and reported stronger mystical experiences with psilocybin compared to methylphenidate.
- Published
- Journal
- Scientific Data
- Authors
- Chacko, R., Dosenbach, N. U. F., Flavin, K., Horan, C., Laumann, T. O., Lenze, E. J., Metcalf, N., Nicol, G., Perry, D., Renau, T. R., Schweiger, J., Siegel, J. S., Snyder, A. Z., Subramanian, S.