Scientific Data

PsiConnect: Multimodal Neuroimaging of Context-Dependent Brain and Behaviour Dynamics under Psilocybin

Published

May 21, 2026

Journal

Scientific Data

Authors

Novelli, L., Stoliker, D., Barta, T., Greaves, M. D., Chopra, S., Jackson, J., Kwee, J., Pang, J. C., Williams, M. L., Razi, A.

Psilocybin’s acute and persistent brain effects: a precision imaging drug trial

This randomised, cross-over study (n=7) used precision functional mapping with high-resolution multi-echo fMRI to characterise psilocybin (25mg) versus methylphenidate effects on brain networks, revealing decreased network modularity during psilocybin exposure and reproducible network changes. Participants showed unique brain configurations and reported stronger mystical experiences with psilocybin compared to methylphenidate.

Published

June 5, 2025

Journal

Scientific Data

Authors

Subramanian, S., Renau, R., Perry, D., Chacko, R., Laumann, T. O., Flavin, K., Horan, C., Schweiger, J., Metcalf, N., Lenze, E. J., Snyder, A. Z., Dosenbach, N. U. F., Nicol, G., Siegel, J. S.

The Altered States Database: Psychometric data from a systematic literature review

This paper (2022) presents the development of the Altered State Database (ASDB). The ASDB was developed through a systematic literature review of psychometric questionnaire data on subjective experiences of altered states of consciousness (ASC). The ASDB allows for the calculation of comparable psychometric values of ASC experiences and of dose-response relationships of substances inducing ASC.

Published

November 23, 2022

Journal

Scientific Data

Authors

Prugger, J., Derdiyok, E., Dinkelacker, J., Costines, C., Schmidt