The Altered States Database: Psychometric data from a systematic literature review
This paper (2022) presents the development of the Altered State Database (ASDB). The ASDB was developed through a systematic literature review of psychometric questionnaire data on subjective experiences of altered states of consciousness (ASC). The ASDB allows for the calculation of comparable psychometric values of ASC experiences and of dose-response relationships of substances inducing ASC.
Authors
- Prugger, J.
- Derdiyok, E.
- Dinkelacker, J.
Published
Abstract
In this paper, we present the development of the Altered States Database (ASDB), an open-science project based on a systematic literature review. The ASDB contains psychometric questionnaire data on subjective experiences of altered states of consciousness (ASC) induced by pharmacological and non-pharmacological methods. The systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Scientific journal articles were identified through PubMed and Web of Science. We included studies that examined ASC using the following validated questionnaires: Altered States of Consciousness Rating Scale (APZ, 5D-ASC, 11-ASC), Phenomenology of Consciousness Inventory (PCI), Hallucinogen Rating Scale (HRS), or Mystical Experience Questionnaire (MEQ30). The systematic review resulted in the inclusion of a total of 165 journal articles, whereof questionnaire data was extracted and is now available on the Open Science Framework (OSF) website and on the ASDB website, where questionnaire data can be easily retrieved and visualized. This data allows the calculation of comparable psychometric values of ASC experiences and of dose-response relationships of substances inducing ASC.
Research Summary of 'The Altered States Database: Psychometric data from a systematic literature review'
Introduction
Earlier research has increased interest in systematically measuring altered states of consciousness (ASC), which are transient mental states characterised by marked changes in perception, self-experience, time, and sensation and which can be induced pharmacologically (for example by psychedelics) or non-pharmacologically (for example by meditation or sensory deprivation). Standardised, validated questionnaires have been developed to quantify the subjective phenomenology of ASC and to allow comparison across induction methods, study designs, and participant groups. Interest has recently intensified because of both basic science questions about consciousness and clinical trials exploring therapeutic uses of psychedelic drugs. Prugger and colleagues aimed to assemble and harmonise published psychometric questionnaire data on ASC into an open, reusable resource: the Altered States Database (ASDB). The project sought to identify all journal articles reporting questionnaire-based measurements of ASC, extract group-level summary statistics (means, standard deviations) for questionnaire factors and dimensions, and make these data available via the Open Science Framework and a dedicated ASDB website to support cross-study comparisons and dose–response analyses. This paper reports the systematic review methods, the extracted dataset, and the organisation and technical validation of the database.
Expert Research Summaries
Go Pro to access AI-powered section-by-section summaries, editorial takes, and the full research toolkit.
Full Text PDF
Full Paper PDF
Create a free account to open full-text PDFs.
Study Details
- Study Typemeta
- Journal
- APA Citation
Prugger, J., Derdiyok, E., Dinkelacker, J., Costines, C., & Schmidt, T. T. (2022). The Altered States Database: Psychometric data from a systematic literature review. Scientific Data, 9(1). https://doi.org/10.1038/s41597-022-01822-4
References (101)
Papers cited by this study that are also in Blossom
Studerus, E., Gamma, A., Vollenweider, F. X. · PLOS ONE (2010)
Tagliazucchi, E., Roseman, L., Kaelen, M. et al. · Current Biology (2016)
Carhart-Harris, R. L., Erritzoe, D., Williams, T. et al. · PNAS (2012)
Muthukumaraswamy, S. D., Carhart-Harris, R. L., Moran, R. J. et al. · Journal of Neuroscience (2013)
Schmid, Y., Enzler, F., Gasser, P. et al. · Biological Psychiatry (2015)
Majic, T., Schmidt, T. T., Gallinat, J. · Journal of Clinical Psychopharmacology (2015)
Nayak, S., Johnson, M. W. · Pharmacopsychiatry (2020)
Reiff, C. M., Richman, E. E., Nemeroff, C. B. et al. · American Journal of Psychiatry (2020)
Hirschfeld, T., Schmidt, T. T. · Journal of Psychopharmacology (2021)
Strassman, R. J., Qualls, C. R., Uhlenhuth, E. H. et al. · JAMA Psychiatry (1994)
Show all 101 referencesShow fewer
MacLean, K. A., Leoutsakos, J. S., Johnson, M. W. et al. · Journal for the Scientific Study of Religion (2012)
Souza, D. C. D., Pérez, C., Papaseit, E. et al. · Frontiers in Pharmacology (2018)
Reckweg, J., Mason, N. L., van Leeuwen, C. et al. · Frontiers in Pharmacology (2021)
Uthaug, M. V., Lancelotta, R., Szabo, A. et al. · Psychopharmacology (2019)
Uthaug, M. V., Lancelotta, R., van Oorsouw, K. et al. · Psychopharmacology (2019)
Barsuglia, J. P., Davis, A. K., Palmer, R. et al. · Frontiers in Psychology (2018)
Davis, A. K., Barsuglia, J. P., Lancelotta, R. et al. · Journal of Psychopharmacology (2018)
Davis, A. K., So, S., Lancelotta, R. et al. · The American Journal of Drug and Alcohol Abuse (2019)
Riba, J., Rodríguez-Fornells, A., Barbanoj, M. J. · Psychopharmacology (2002)
Valle, M., Maqueda, A. E., Rabella, M. et al. · European Neuropsychopharmacology (2016)
Alonso, J. N., Romero, S., Mañanas, M. A. et al. · International Journal of Neuropsychopharmacology (2015)
Uthaug, M. V., Mason, N. L., Toennes, S. W. et al. · Psychopharmacology (2021)
Barbanoj, M. J., Riba, J., Clos, S. et al. · Psychopharmacology (2007)
Palhano-Fontes, F., Barreto, D., Onias, H. et al. · Psychological Medicine (2018)
Pasquini, L., Palhano-Fontes, F., Araújo, D. B. · Journal of Psychopharmacology (2020)
Riba, J., Urbano, G., Morte, A. et al. · Psychopharmacology (2001)
Riba, J., Anderer, P., Morte, A. et al. · British Journal of Clinical Pharmacology (2002)
Riba, J., Valle, M., Urbano, G. et al. · Journal of Pharmacology and Experimental Therapeutics (2003)
Griffiths, R. R., Hurwitz, E. S., Davis, A. K. et al. · PLOS ONE (2019)
Ruffell, S. G. D., Netzband, N., Tsang, W. et al. · Frontiers in Psychiatry (2021)
Gouzoulis-Mayfrank, E., Heekeren, K., Neukirch, A. et al. · Pharmacopsychiatry (2005)
Pallavicini, C., Cavanna, F., Zamberlan, F. et al. · Journal of Psychopharmacology (2021)
Schenberg, E. E., Alexandre, J. F. M., Filev, R. et al. · PLOS ONE (2015)
Strassman, R. J., Qualls, C. R., Berg, L. M. · Biological Psychiatry (1996)
Carbonaro, T. M., Hurwitz, E., Johnson, M. W. · Psychopharmacology (2017)
Holze, F., Vizeli, P., Müller, F. et al. · Neuropsychopharmacology (2019)
Gouzoulis-Mayfrank, E., Thelen, B., Habermeyer, E. et al. · Psychopharmacology (1999)
Pokorny, T., Preller, K. H., Kraehenmann, R. et al. · European Neuropsychopharmacology (2016)
Schmidt, T. T., Reiche, S., Hage, L. T. et al. · Scientific Reports (2020)
Höflich, A., Hahn, A., Küblböck, M. et al. · International Journal of Neuropsychopharmacology (2015)
Lehmann, M., Neumann, C., Wasserthal, S. et al. · Neuroscience of Consciousness (2021)
Mueller, F., Musso, F., London, M. et al. · NeuroImage (2018)
Bowdle, A. T., Radant, A. D., Cowley, D. S. et al. · Anesthesiology (1998)
Krupitsky, E. M., Burakov, A. M., Romanova, T. N. et al. · Journal of Substance Abuse Treatment (2002)
Family, N., Maillet, E. L., Williams, L. T. J. et al. · Psychopharmacology (2019)
Holze, F., Vizeli, P., Ley, L. et al. · Neuropsychopharmacology (2020)
Liechti, M. E., Dolder, P. C., Schmid, Y. · Psychopharmacology (2016)
Lenz, C., Dolder, P. C., Lang, U. E. et al. · Acta Psychiatrica Scandinavica (2017)
Schmid, Y., Gasser, P., Oehen, P. et al. · Journal of Psychopharmacology (2020)
Bershad, A. K., Preller, K. H., Lee, R. et al. · Biological Psychiatry (2020)
Carhart-Harris, R. L., Kaelen, M., Bolstridge, M. et al. · Psychological Medicine (2016)
Carhart-Harris, R. L., Muthukumaraswamy, S., Roseman, L. et al. · PNAS (2016)
Hutten, N. R. P. W., Mason, N. L., Dolder, P. C. et al. · European Neuropsychopharmacology (2020)
Sumiyoshi, T., Kraehenmann, R., Pokorny, D. et al. · Frontiers in Pharmacology (2017)
Perry, C. M., Malina, M. · Psychopharmacology (2021)
Preller, K. H., Burt, J. B., Adkinson, B. et al. · eLife (2018)
Preller, K. H., Schilbach, L., Pokorny, T. et al. · Journal of Neuroscience (2018)
Preller, K. H., Herdener, M., Pokorny, T. et al. · Current Biology (2017)
Bershad, A. K., Schepers, S. T., Bremmer, M. P. et al. · Biological Psychiatry (2019)
Baggott, M. J., Siegrist, J. D., Galloway, G. P. et al. · PLOS ONE (2010)
Baggott, M. J., Garrison, K. J., Coyle, J. R. et al. · Journal of Psychoactive Drugs (2019)
Dolder, P. C., Müller, F., Schmid, Y. et al. · Psychopharmacology (2017)
Hasler, F., Ludewig, S. · Journal of Psychopharmacology (2008)
Liechti, M. E., Baumann, C., Gamma, A. et al. · Neuropsychopharmacology (2000)
Liechti, M. E., Gamma, A., Vollenweider, F. X. · Psychopharmacology (2001)
Bouso, J. C., Doblin, R., Farré, M. et al. · Journal of Psychoactive Drugs (2008)
Bravermanová, A., Viktorinová, M., Tylš, F. et al. · Psychopharmacology (2018)
Griffiths, R. R., Richards, W. A., Mccann, U. et al. · Journal of Psychopharmacology (2006)
Griffiths, R. R., Johnson, M. W., Richards, W. A. et al. · Psychopharmacology (2011)
Schmidt, A., Kometer, M., Bachmann, R. et al. · Psychopharmacology (2012)
Bogenschutz, M. P., Forcehimes, A. A., Pommy, J. A. et al. · Journal of Psychopharmacology (2015)
Carhart-Harris, R. L., Williams, T. M., Sessa, B. et al. · Journal of Psychopharmacology (2010)
Griffiths, R. R., Johnson, M. W., Richards, W. A. et al. · Journal of Psychopharmacology (2017)
Grob, C. S., Danforth, A. L., Chopra, G. S. et al. · JAMA Psychiatry (2011)
Hasler, F., Grimberg, U., Benz, M. A. et al. · Psychopharmacology (2004)
Quednow, B. B., Kometer, M., Geyer, M. A. et al. · Neuropsychopharmacology (2011)
Smigielski, L., Kometer, M., Scheidegger, M. et al. · Scientific Reports (2019)
Vollenweider, F. X., Csomor, P. A., Knappe, B. et al. · Neuropsychopharmacology (2007)
Wittmann, M., Carter, O., Hasler, F. et al. · Journal of Psychopharmacology (2007)
Carter, O., Burr, D. C., Pettigrew, J. D. et al. · Journal of Cognitive Neuroscience (2006)
Carter, O. L., Hasler, F. ;., Pettigrew, J. D. et al. · Psychopharmacology (2007)
Bernasconi, F. ;., Schmidt, A. ;., Pokorny, T. ;. et al. · Cerebral Cortex (2013)
Carhart-Harris, R. L., Bolstridge, &. M., Day, C. M. J. et al. · Psychopharmacology (2017)
Kometer, M., Schmidt, A., Bachmann, R. et al. · Biological Psychiatry (2012)
Lewis, C. R., Preller, K. H., Braden, B. B. et al. · Biomedicines (2020)
Lewis, C. R., Preller, K. H., Kraehenmann, R. et al. · NeuroImage (2017)
Madsen, M. K., Fisher, P. M., Burmester, D. et al. · Neuropsychopharmacology (2019)
Madsen, M. K., Fisher, P. M., Stenbæk, D. S. et al. · European Neuropsychopharmacology (2020)
Madsen, M. K., Stenbaek, D. S., Arvidsson, A. et al. · European Neuropsychopharmacology (2021)
Preller, K. H., Pokorny, D., Hock, A. et al. · PNAS (2016)
Pokorny, T., Preller, K. H., Kometer, M. et al. · International Journal of Neuropsychopharmacology (2017)
Moreno, F. A., Wiegand, C. B., Taitano, E. K. et al. · Journal of Clinical Psychiatry (2006)
Olson, J. A., Suissa-Rocheleau, L., Lifshitz, M. et al. · Psychopharmacology (2020)
Smigielski, L., Kometer, M., Scheidegger, M. et al. · Human Brain Mapping (2020)
Nicholas, C. R., Henriquez, K. M., Gassman, M. C. et al. · Journal of Psychopharmacology (2018)
Ross, S., Bossis, A. P., Guss, J. et al. · Journal of Psychopharmacology (2016)
Maclean, K. A., Johnson, M. W., Reissig, C. J. et al. · Psychopharmacology (2012)
Maqueda, A. E., Valle, M., Addy, P. H. et al. · International Journal of Neuropsychopharmacology (2015)
Johnson, M. W., Maclean, K. A., Reissig, C. J. et al. · Drug and Alcohol Dependence (2011)
Ona, G., Sampedro, F., Romero, S. et al. · International Journal of Neuropsychopharmacology (2021)
Pasquini, L., Luke, D., Harris, R. E. et al. · Frontiers in Human Neuroscience (2021)
Cited By (1)
Papers in Blossom that reference this study
Pasquini, L., Simon, A. J., Gallen, C. L. et al. · Biorxiv (2024)
Your Personal Research Library
Go Pro to save papers, add notes, rate studies, and organize your research into custom shelves.