Ketamine-induced modulation of the thalamo-cortical network in healthy volunteers as a model for schizophrenia
This double-blind, randomised, placebo-controlled, within-subjects crossover study (n=30) investigated the effects of esketamine (23.1mg/70kg) on the modulation of thalamocortical circuitry during resting state in healthy volunteers, to investigate whether their brain connectivity exhibits a similar profile as patients with schizophrenia. They found that a subanesthetic dose of ketamine leads to significantly higher functional connectivity in the thalamus hub network, and the strengthening of functional cortico-thalamic connectivity for the somatosensory and temporal seed regions but not for prefrontal, occipital, and parietal regions, in accordance with the connectivity profile of schizophrenia.
9 cited-by links indexed in Blossom
Authors
- Siegfried Kasper
Published
Abstract
Background
Schizophrenia has been associated with disturbances of thalamic functioning. In light of recent evidence suggesting a significant impact of the glutamatergic system on key symptoms of schizophrenia, we assessed whether modulation of the glutamatergic system via blockage of the N-methyl-D-aspartate (NMDA)-receptor might lead to changes of thalamic functional connectivity.
Methods
Based on the ketamine model of psychosis, we investigated changes in cortico-thalamic functional connectivity by intravenous ketamine challenge during a 55-minute resting-state scan. Thirty healthy volunteers were measured with pharmacological functional magnetic resonance imaging using a double-blind, randomized, placebo-controlled, crossover design.
Results
Functional connectivity analysis revealed significant ketamine-specific changes within the thalamus hub network, more precisely, an increase of cortico-thalamic connectivity of the somatosensory and temporal cortex.
Conclusions
Our results indicate that changes of thalamic functioning as described for schizophrenia can be partly mimicked by NMDA-receptor blockage. This adds substantial knowledge about the neurobiological mechanisms underlying the profound changes of perception and behavior during the application of NMDA-receptor antagonists.
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Study Details
- Study Typeindividual
- Populationhumans
- Characteristicsdouble blindrandomizedplacebo controlledcrossoverbrain measures
- Journal
- Compound
- Topics
- Author
- APA Citation
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Cited By (9)
Papers indexed in Blossom that reference this study.
Moujaes, F., Lisa, J., Rahmati, M. et al. · eLife (2024)
Prugger, J., Derdiyok, E., Dinkelacker, J. et al. · Scientific Data (2022)
Dourron, H. M., Strauss, C., Hendricks, P. S. · Pharmacological Reviews (2022)
Li, D., Vlisides, P. E., Mashour, G. A. · NeuroImage (2022)
Avram, M., Rogg, H., Korda, A. et al. · Frontiers in Psychiatry (2021)
Lehmann, M., Neumann, C., Wasserthal, S. et al. · Neuroscience of Consciousness (2021)
Nichols, D. E., Walter, H. · Pharmacopsychiatry (2020)
Kadriu, B., Greenwald, M., Ba et al. · International Journal of Neuropsychopharmacology (2020)
Kraus, C., Rabl, U., Vanicek, T. et al. · International Journal of Psychiatry in Clinical Practice (2017)
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