AyahuascaLSDPsilocybin

Survey of subjective “God encounter experiences”: Comparisons among naturally occurring experiences and those occasioned by the classic psychedelics psilocybin, LSD, ayahuasca, or DMT

This survey study (n=4258) compares natural (non-drug) and psychedelic (LSD, psilocybin, ayahuasca, DMT) reported God encounter experiences and finds very similar descriptions. For half of the participants the experience qualified as a full mystical experience, more than 67% of participants who identified as atheists didn't do so after the experience (e.g. became agnostic).

Authors

  • Roland Griffiths
  • Matthew Johnson
  • Alan Davis

Published

PLOS ONE
individual Study

Abstract

Naturally occurring and psychedelic drug-occasioned experiences interpreted as personal encounters with God are well described but have not been systematically compared. In this study, five groups of individuals participated in an online survey with detailed questions characterizing the subjective phenomena, interpretation, and persisting changes attributed to their single most memorable God encounter experience (n = 809 Non-Drug, 1184 psilocybin, 1251 lysergic acid diethylamide (LSD), 435 ayahuasca, and 606 N,N-dimethyltryptamine (DMT)). Analyses of differences in experiences were adjusted statistically for demographic differences between groups. The Non-Drug Group was most likely to choose God as the best descriptor of that which was encountered while the psychedelic groups were most likely to choose Ultimate Reality. Although there were some other differences between non-drug and the combined psychedelic group, as well as between the four psychedelic groups, the similarities among these groups were most striking. Most participants reported vivid memories of the encounter experience, which frequently involved communication with something having the attributes of being conscious, benevolent, intelligent, sacred, eternal, and all-knowing. The encounter experience fulfilled a priori criteria for being a complete mystical experience in approximately half of the participants. More than two-thirds of those who identified as atheist before the experience no longer identified as atheist afterwards. These experiences were rated as among the most personally meaningful and spiritually significant lifetime experiences, with moderate to strong persisting positive changes in life satisfaction, purpose, and meaning attributed to these experiences. Among the four groups of psychedelic users, the psilocybin and LSD groups were most similar and the ayahuasca group tended to have the highest rates of endorsing positive features and enduring consequences of the experience. Future exploration of predisposing factors and phenomenological and neural correlates of such experiences may provide new insights into religious and spiritual beliefs that have been integral to shaping human culture since time immemorial.

Available with Blossom Pro

Research Summary of 'Survey of subjective “God encounter experiences”: Comparisons among naturally occurring experiences and those occasioned by the classic psychedelics psilocybin, LSD, ayahuasca, or DMT'

Introduction

Salient personal experiences interpreted as encounters with God, gods, or emissaries of God have long been described in religious history and overlap in many respects with mystical-type experiences. Earlier empirical research has focused on naturally occurring mystical experiences and on psychedelic-occasioned mystical states, including laboratory studies showing that psilocybin can reliably occasion mystical experiences measured with instruments such as the Hood M Scale and the Mystical Experience Questionnaire (MEQ30). Debate persists among scholars as to whether drug-occasioned experiences should be considered genuine religious or mystical experiences, in part because classical definitions of mystical experience sometimes exclude visions and voice phenomena. Griffiths and colleagues conducted a large cross-sectional internet survey to characterise and directly compare single, memorable God encounter experiences that were either naturally occurring (non-drug) or occurred after ingestion of a classic psychedelic (psilocybin, LSD, ayahuasca, or DMT). The investigators aimed to describe demographic and phenomenological features of these encounters, test whether they meet a priori criteria for a complete mystical experience (MEQ30 ≥60% on all four subscales), compare interpretation and persisting consequences between non-drug and psychedelic-occasioned encounters, and explore differences among the four psychedelic substances.

Expert Research Summaries

Go Pro to access AI-powered section-by-section summaries, editorial takes, and the full research toolkit.

Full Text PDF

Full Paper PDF

Create a free account to open full-text PDFs.

Study Details

  • Study Type
    individual
  • Journal
  • Compounds
  • Authors
  • APA Citation

    Griffiths, R. R., Hurwitz, E. S., Davis, A. K., Johnson, M. W., & Jesse, R. (2019). Survey of subjective “God encounter experiences”: Comparisons among naturally occurring experiences and those occasioned by the classic psychedelics psilocybin, LSD, ayahuasca, or DMT. PLOS ONE, 14(4), e0214377. https://doi.org/10.1371/journal.pone.0214377

References (13)

Papers cited by this study that are also in Blossom

Chemistry and Structure-Activity Relationships of Psychedelics

Nichols, D. E. · Current Topics in Behavioral Neurosciences (2017)

78 cited
Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance

Griffiths, R. R., Richards, W. A., Mccann, U. et al. · Journal of Psychopharmacology (2006)

Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects

Griffiths, R. R., Johnson, M. W., Richards, W. A. et al. · Psychopharmacology (2011)

Factor analysis of the mystical experience questionnaire: A study of experiences occasioned by the hallucinogen psilocybin

MacLean, K. A., Leoutsakos, J. S., Johnson, M. W. et al. · Journal for the Scientific Study of Religion (2012)

350 cited
Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin

Barrett, F. S., Johnson, M. W., Griffiths, R. R. · Journal of Psychopharmacology (2015)

Human hallucinogen research: guidelines for safety

Johnson, M. W., Richards, W. A., Griffiths, R. R. · Journal of Psychopharmacology (2008)

Ayahuasca: pharmacology, neuroscience and therapeutic potential

Domínguez-Clavé, E., Soler, J., Elices, M. et al. · Brain Research Bulletin (2016)

Show all 13 references
Dimethyltryptamine (DMT): Prevalence, user characteristics and abuse liability in a large global sample

Winstock, A. R., Kaar, S., Borschmann, R. · Journal of Psychopharmacology (2013)

89 cited
Survey study of challenging experiences after ingesting psilocybin mushrooms: Acute and enduring positive and negative consequences

Carbonaro, T. M., Bradstreet, M. P., Barrett, F. S. et al. · Journal of Psychopharmacology (2016)

The Challenging Experience Questionnaire: Characterization of challenging experiences with psilocybin mushrooms

Barrett, F. S., Bradstreet, M. P., Leoutsakos, J. M. S. et al. · Journal of Psychopharmacology (2016)

Cited By (54)

Papers in Blossom that reference this study

Roland R. Griffiths, psychopharmacology pioneer: Abuse liability, alcohol, nicotine, caffeine, benzodiazepines, and psychedelics

Henningfield, J. E., Barrett, F. S., Evans, S. M. et al. · Journal of Psychopharmacology (2026)

1 cited
Mixed-methods analysis on psychedelic-augmented meditation experiences from a randomized controlled mindfulness retreat

Schlomberg, J. T. T., Meling, D., Grylka, R. et al. · Scientific Reports (2026)

Psychedelics are associated with changes in spiritual beliefs and orientations in US veterans

Brown, R. E., Shinozuka, K., Kaloiani, I. et al. · Research Square (2026)

Effects of Psilocybin on Religious and Spiritual Attitudes and Behaviors in Clergy from Various Major World Religions

Griffiths, R. R., Jesse, R., Richards, W. A. et al. · Psychedelic Medicine (2026)

12 cited
Intact neurophysiological markers of death denial in long-term ayahuasca users

Dor-Ziderman, Y., David, J., Berkovich-Ohana, A. · Psychopharmacology (2025)

6 cited
Clinically relevant acute subjective effects of psychedelics beyond mystical experience

Yaden, D. B., Goldy, S. P., Weiss, B. et al. · Nature Reviews Psychology (2024)

How Do Psychedelics Reduce Fear of Death?

Letheby, C. · Neuroethics (2024)

11 cited
Psychedelic Experiences Increase Mind Perception but do not Change Atheist-Believer Status: A Prospective Longitudinal Study

Nayak, S., Jackson, H., Griffiths, R. R. et al. · Journal of Psychoactive Drugs (2024)

Show all 54 papers
What Predicts Beneficial Outcomes in Psychedelic Use? A Quantitative Content Analysis of Psychedelic Health Outcomes

Acevedo, E. C., Uhler, S., White, K. et al. · Journal of Psychoactive Drugs (2024)

Epidemiology of classic psychedelic substances: results from a Norwegian internet convenience sample

Kvam, T-M., Uthaug, M. V., Andersen, K. A. A. et al. · Frontiers in Psychiatry (2023)

17 cited
Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences

Zeifman, R. J., Kettner, H., Pagni, B. A. et al. · Scientific Reports (2023)

22 cited
N, N-Dimethyltryptamine (DMT)-Occasioned Familiarity and the Sense of Familiarity Questionnaire (SOF-Q)

Lawrence, D. W., Timmermann, C. · Journal of Psychoactive Drugs (2023)

Transpersonal Ecodelia: Surveying Psychedelically Induced Biophilia

Luke, D., Gandy, S., Irvine, A. et al. · Psychoactives (2023)

17 cited
Dose-response relationships of LSD-induced subjective experiences in humans

Prugger, J., Hirschfeld, T., Majic, T. et al. · Neuropsychopharmacology (2023)

19 cited
Canalization and plasticity in psychopathology

Carhart-Harris, R. L., Chandaria, S., Erritzoe, D. E. et al. · Neuropharmacology (2023)

Psychedelics and psychological strengths

Brasher, T., Rosen, D., Spinella, M. · International Journal of Wellbeing (2023)

The Altered States Database: Psychometric data from a systematic literature review

Prugger, J., Derdiyok, E., Dinkelacker, J. et al. · Scientific Data (2022)

Belief changes associated with psychedelic use

Nayak, S., Singh, M., Yaden, D. B. et al. · Journal of Psychopharmacology (2022)

Group VR experiences can produce ego attenuation and connectedness comparable to psychedelics

Glowacki, D. R., Wonnacott, M. D., Freire, R. et al. · Scientific Reports (2022)

31 cited
Psychedelics and Psychotherapy: Cognitive-Behavioral Approaches as Default

Yaden, D. B., Earp, D., Graziosi, M. et al. · Frontiers in Psychology (2022)

Phenomenology and Content of the Inhaled N, N-Dimethyltryptamine (N, N-DMT) Experience

Lawrence, D. W., Carhart-Harris, R. L., Griffiths, R. R. et al. · Research Square (2022)

Predictors and potentiators of psychedelic-occasioned mystical experiences

Gandy, S. · Journal of Psychedelic Studies (2022)

Psilocybin-Induced Mystical-Type Experiences are Related to Persisting Positive Effects: A Quantitative and Qualitative Report

McCulloch, D. E-W., Madsen, M. K., Jensen, P. S. et al. · Frontiers in Pharmacology (2022)

79 cited
Presence, Trust, and Empathy: Preferred Characteristics of Psychedelic Carers

Thal, S., Engels, L. B., Bright, S. J. · Journal of Humanistic Psychology (2022)

Psychedelics, sociality, and human evolution

Rodríguez Arce, J. M., Winkelman, M. J. · Frontiers in Psychology (2021)

Psychedelics alter metaphysical beliefs

Timmermann, C., Kettner, H., Letheby, C. et al. · Scientific Reports (2021)

Psychedelic perceptions: mental health service user attitudes to psilocybin therapy

Corrigan, K., Haran, M., Mccandliss, C. et al. · Irish Journal of Medical Science (2021)

Protocol for Outcome Evaluation of Ayahuasca-Assisted Addiction Treatment: The Case of Takiwasi Center

Rush, B., Marcus, O., García, S. et al. · Frontiers in Pharmacology (2021)

19 cited
Psychedelics and Consciousness: Distinctions, Demarcations, and Opportunities

Yaden, D. B., Johnson, M. W., Griffiths, R. R. et al. · International Journal of Neuropsychopharmacology (2021)

The Shipibo Ceremonial Use of Ayahuasca to Promote Well-Being: An Observational Study

González, D., Cantillo, J., Perez, I. et al. · Frontiers in Pharmacology (2021)

Baseline power of theta oscillations predicts mystical-type experiences induced by DMT in a natural setting

Tagliazucchi, E., Zamberlan, F., Cavanna, F. et al. · Frontiers in Psychiatry (2021)

Predicting Reactions to Psychedelic Drugs: A Systematic Review of States and Traits Related to Acute Drug Effects

Aday, J. S., Davis, A. K., Mitzkovitz, C. M. et al. · ACS Pharmacology and Translational Science (2021)

Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings

Pallavicini, C., Cavanna, F., Zamberlan, F. et al. · Journal of Psychopharmacology (2021)

People of color in North America report improvements in racial trauma and mental health symptoms following psychedelic experiences

Williams, T. M., Davis, A. K., Xin, Y. et al. · Drugs Education Prevention and Policy (2020)

Pivotal Mental States

Brouwer, A., Carhart-Harris, R. L. · Journal of Psychopharmacology (2020)

Compassionate use of psychedelics

Greif, A., Šurkala, M. · Medicine Health Care and Philosophy (2020)

Isness: Using Multi-Person VR to Design Peak Mystical Type Experiences Comparable to Psychedelics

Glowacki, D. R., Wonnacott, M. D., Freire, R. et al. · Association for Computing Machinery (2020)

32 cited
Long-term effects of psychedelic drugs: A systematic review

Aday, J. S., Mitzkovitz, C. M., Bloesch, E. K. et al. · Neuroscience and Biobehavioral Reviews (2020)

Your Personal Research Library

Go Pro to save papers, add notes, rate studies, and organize your research into custom shelves.