Depressive DisordersAyahuasca

The Shipibo Ceremonial Use of Ayahuasca to Promote Well-Being: An Observational Study

In an observational study of Western participants attending a Shipibo ayahuasca healing programme, scores for psychological well‑being, happiness, spirituality and quality of life increased significantly and remained elevated up to 12 months post‑stay. Improvements were associated with greater decentering (r = 0.57) and subgroup analyses suggest the changes were attributable to the centre stay rather than the mere passage of time.

Authors

  • Amanda Feilding
  • Magí Farré
  • José Carlos Bouso

Published

Frontiers in Pharmacology
individual Study

Abstract

Promoting well-being is one of the main goals to improve health in the world. We examined the well-being and quality of life over the course of one year in a sample that participated in an Indigenous Shipibo healing program where traditional healers work in a series of ayahuasca ceremonies. We also explored the role of decentering as a mediator of psychological well-being. Participants who attended the program responded to an online survey that included a Psychological Well-Being Scale; Oxford Happiness Questionnaire; The World Health Organization Quality of Life Spirituality, Religiousness, and Personal Beliefs scale; the WHO Quality of Life-BREF scale; and Decentering scale. Baseline (T0) and postassessment (T1) were completed by 200 individuals. Of these, 101 completed the follow-up assessment at three months (T2), 91 at 6 months (T3), and 94 at 12 months follow-up (T4) after leaving the center. ANOVA test was performed in a representative subsample to control the passing of time two months before attending the program (T-1). Pearson’s test was performed to examine the relationship between psychological well-being and decentering during the period of T0 and T1. A significant increase was observed in all the scales at all time points (p≤ 0.01). The subgroup analysis performed in a representative subsample allowed us to infer that the significant differences in outcomes are due to the effect of their stay at the center and not the passing of time. We found a relationship between decentering and the improvement of psychological well-being (r= 0.57;p< 0.01). Our results suggest that the Indigenous Shipibo healing work with ayahuasca has value to improve long-term well-being and quality of life for Westerners.

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Research Summary of 'The Shipibo Ceremonial Use of Ayahuasca to Promote Well-Being: An Observational Study'

Introduction

Gonzalez and colleagues frame this study within growing international interest in promoting well-being as a core public‑health and clinical objective. They contrast two traditions in well‑being research—the eudaimonic model (focusing on personal growth, autonomy, purpose and related constructs) and the hedonic model (focusing on life satisfaction and positive affect)—and note that both are relevant for comprehensive measurement. The authors situate ayahuasca within the wider category of traditional medicine, review its botanical composition (Banisteriopsis caapi and Psychotria viridis), prior evidence of safety from long‑term ceremonial use and laboratory studies, and emerging clinical findings that ayahuasca can have rapid antidepressant effects. They also note the global spread of ayahuasca practices and attendant concerns about cultural appropriation, variable practitioner competence, and lack of regulation. This prospective observational study set out to evaluate whether participation in a series of Shipibo‑led ayahuasca ceremonies at the Temple of the Way of Light (Iquitos, Peru) is associated with changes in multiple dimensions of well‑being over one year. The primary outcome was psychological well‑being; secondary outcomes included subjective happiness, spiritual well‑being, quality of life, and decentering. The investigators additionally planned to explore whether changes in decentering were associated with, and potentially mediated, changes in psychological well‑being. The study is presented as complementary to randomised trials, aiming to examine outcomes in a naturalistic, traditional healing context.

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