Psychedelics and Consciousness: Distinctions, Demarcations, and Opportunities

This review (2021) examines the usage and the meaning of the term 'consciousness' within psychedelic research and how theories of consciousness are operationalized to explain the effects of psychedelics in turn. Although psychedelics are unlikely to elucidate the biological basis for phenomenal consciousness (i.e. the hard problem), they are useful tools for investigating claims about the contents of consciousness, and their altered states.

Authors

  • Albert Garcia-Romeu
  • Roland Griffiths
  • Matthew Johnson

Published

International Journal of Neuropsychopharmacology
meta Study

Abstract

Psychedelic substances produce unusual and compelling changes in conscious experience which have prompted some to propose that psychedelics may provide unique insights explaining the nature of consciousness. At present, psychedelics, like other current scientific tools and methods, seem unlikely to provide information relevant to the so-called “hard problem of consciousness,” which involves explaining how first-person experience can emerge. However, psychedelics bear on multiple “easy problems of consciousness,” which involve relations between subjectivity, brain function, and behaviour. In this review, we discuss common meanings of the term consciousness when used with regard to psychedelics and consider some models of the effects of psychedelics on the brain that have also been associated with explanatory claims about consciousness. We conclude by calling for epistemic humility regarding the potential for psychedelic research to aid in explaining the hard problem of consciousness while pointing to ways in which psychedelics may advance the study of many specific aspects of consciousness.

Available with Blossom Pro

Research Summary of 'Psychedelics and Consciousness: Distinctions, Demarcations, and Opportunities'

Introduction

Yaden and colleagues frame the paper by noting renewed scientific interest in psychedelic substances and their striking effects on subjective experience. They observe that some commentators and popular books suggest psychedelics might illuminate the nature of consciousness, but they caution that the term "consciousness" is used in multiple, often conflated ways. The authors set out to clarify these different senses of consciousness and to evaluate what psychedelic research can and cannot reasonably contribute, distinguishing between the so-called "hard problem" (explaining phenomenal experience itself) and a variety of "easy problems" (mechanistic questions about perception, attention, selfhood and related contents of consciousness). The review aims to assess philosophical distinctions, neuroscientific models proposed to explain psychedelic effects, and empirical findings about subjective psychedelic states. Throughout, the investigators emphasise the need for epistemic humility: to separate modest, testable scientific claims about the contents and functions of consciousness from stronger claims about solving the hard problem of how subjective experience arises.

Expert Research Summaries

Go Pro to access AI-powered section-by-section summaries, editorial takes, and the full research toolkit.

Full Text PDF

Full Paper PDF

Create a free account to open full-text PDFs.

Study Details

References (26)

Papers cited by this study that are also in Blossom

Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin

Barrett, F. S., Johnson, M. W., Griffiths, R. R. · Journal of Psychopharmacology (2015)

Dimensions of consciousness and the psychedelic state

Bayne, T., Carter, O. · Neuroscience of Consciousness (2018)

106 cited
Neural correlates of the LSD experience revealed by multimodal neuroimaging

Carhart-Harris, R. L., Muthukumaraswamy, S., Roseman, L. et al. · PNAS (2016)

The entropic brain - revisited

Carhart-Harris, R. L. · Neuropharmacology (2018)

REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics

Carhart-Harris, R. L., Friston, K. J. · Pharmacological Reviews (2019)

Serotonin research: contributions to understanding psychoses

Geyer, M. A., Vollenweider, F. X. · Trends in Pharmacological Sciences (2008)

Consciousness, Religion, and Gurus: Pitfalls of Psychedelic Medicine

Johnson, M. W. · ACS Pharmacology and Translational Science (2020)

Show all 26 references
Potential Therapeutic Effects of Psilocybin

Johnson, M. W., Griffiths, R. R. · Neurotherapeutics (2017)

Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function

Johnson, M. W., Hendricks, P. S., Barrett, F. S. et al. · Pharmacology and Therapeutics (2019)

Increased thalamic resting state connectivity as a core driver of LSD-induced hallucinations

Lenz, C., Dolder, P. C., Lang, U. E. et al. · Acta Psychiatrica Scandinavica (2017)

Broadband Cortical Desynchronization Underlies the Human Psychedelic State

Muthukumaraswamy, S. D., Carhart-Harris, R. L., Moran, R. J. et al. · Journal of Neuroscience (2013)

427 cited
Psychedelics and Psychotherapy

Nayak, S., Johnson, M. W. · Pharmacopsychiatry (2020)

Ego-dissolution and psychedelics: validation of the ego-dissolution inventory (EDI)

Nour, M. R., Evans, J., Nutt, D. J. et al. · Frontiers in Human Neuroscience (2016)

A review of the clinical effects of psychotomimetic agents

Osmond, H. · Annals of the New York Academy of Sciences (2010)

296 cited
Effective connectivity changes in LSD-induced altered states of consciousness in humans

Preller, K. H., Razi, A., Zeidman, P. et al. · PNAS (2019)

Topographic pharmaco-EEG mapping of the effects of the South American psychoactive beverage ayahuasca in healthy volunteers

Riba, J., Anderer, P., Morte, A. et al. · British Journal of Clinical Pharmacology (2002)

Psychedelics as a treatment for disorders of consciousness

Scott, G., Carhart-Harris, R. L. · Neuroscience of Consciousness (2019)

Prediction of psilocybin response in healthy volunteers

Studerus, E., Gamma, A., Kometer, M. et al. · PLOS ONE (2012)

Increased global functional connectivity correlates with LSD-induced ego dissolution

Tagliazucchi, E., Roseman, L., Kaelen, M. et al. · Current Biology (2016)

Cited By (6)

Papers in Blossom that reference this study

Your Personal Research Library

Go Pro to save papers, add notes, rate studies, and organize your research into custom shelves.