Depressive DisordersSchizophreniaEquity and EthicsPersonality & Trait Factors

Predicting Reactions to Psychedelic Drugs: A Systematic Review of States and Traits Related to Acute Drug Effects

This review (14 studies) found that traits of absorption, openness, acceptance, and surrender correlated with more positive and mystical (MEQ30) experiences. Gender didn't predict drug effects, but possible biomarkers are serotonin receptor binding potential, executive network node diversity, and right anterior cingulate cortex volume.

Authors

  • Alan Davis
  • Jordan Aday
  • Emily Bloesch

Published

ACS Pharmacology and Translational Science
meta Study

Abstract

Psychedelic drugs are increasingly being incorporated into therapeutic contexts for the purposes of promoting mental health. However, they can also induce adverse reactions in some individuals, and it is difficult to predict before treatment who is likely to experience positive or adverse acute effects. Although consideration of setting and dosage as well as excluding individuals with psychotic predispositions has thus far led to a high degree of safety, it is imperative that researchers develop a more nuanced understanding of how to predict individual reactions. To this end, the current systematic review coalesced the results of 14 studies that included baseline states or traits predictive of the acute effects of psychedelics. Individuals high in the traits of absorption, openness, and acceptance as well as a state of surrender were more likely to have positive and mystical-type experiences, whereas those low in openness and surrender or in preoccupied, apprehensive, or confused psychological states were more likely to experience acute adverse reactions. Participant sex was not a robust predictor of drug effects, but 5-HT2AR binding potential, executive network node diversity, and rACC volume may be potential baseline biomarkers related to acute reactions. Finally, increased age and experience with psychedelics were individual differences related to generally less intense effects, indicating that users may become slightly less sensitive to the effects of the drugs after repeated usage. Although future well-powered, placebo-controlled trials directly comparing the relative importance of these predictors is needed, this review synthesizes the field’s current understanding of how to predict acute reactions to psychedelic drugs.

Available with Blossom Pro

Research Summary of 'Predicting Reactions to Psychedelic Drugs: A Systematic Review of States and Traits Related to Acute Drug Effects'

Introduction

Classic psychedelic substances such as psilocybin, LSD, ayahuasca/DMT, and mescaline can produce a wide range of cognitive, emotional and neurological effects. Interest in their therapeutic potential has re-emerged after decades of prohibition, driven by preliminary findings for conditions like depression and substance misuse. At the same time, psychedelic sessions can be psychologically challenging for some individuals, and current practices—careful attention to dosage and setting, plus excluding those with psychotic predispositions—have reduced but not eliminated adverse acute reactions. The introduction highlights that there remains limited understanding of which baseline states or traits predict whether an individual will have a positive, mystical-type response or a difficult, adverse reaction. Aday and colleagues framed the review to synthesise contemporary empirical work that tests predrug (baseline) variables as predictors of acute psychedelic effects. The stated aim was to identify replicable states, traits, and potential biomarkers that might inform screening or preparatory procedures in clinical and research contexts, thereby improving safety, optimising therapeutic benefit, and reducing ineffective treatments as psychedelics are integrated into medical settings.

Expert Research Summaries

Go Pro to access AI-powered section-by-section summaries, editorial takes, and the full research toolkit.

See Pro PlansAlready have an account? Sign in

Full Text PDF

Full Paper PDF

Create a free account to open full-text PDFs.

Create Free AccountAlready have an account? Sign in

Study Details

References (55)

Papers cited by this study that are also in Blossom

Psychological flexibility mediates the relations between acute psychedelic effects and subjective decreases in depression and anxiety

Davis, A. K., Barrett, F. S., Griffiths, R. R. · Journal of Contextual Behavioral Science (2020)

Emotional breakthrough and psychedelics: validation of the emotional breakthrough inventory

Roseman, L., Haijen, E. C. H. M., Idialu-Ikato, K. et al. · Journal of Psychopharmacology (2019)

Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin

Carhart-Harris, R. L., Erritzoe, D., Williams, T. et al. · PNAS (2012)

Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder

Davis, A. K., Barrett, F. S., May, D. G. et al. · JAMA Psychiatry (2021)

1015 cited
Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction

Johnson, M. W., Garcia-Romeu, A., Cosimano, M. P. et al. · Journal of Psychopharmacology (2014)

Psilocybin-assisted group therapy for demoralized older long-term AIDS survivor men: An open-label safety and feasibility pilot study

Anderson, B. T., Danforth, A. L., Daroff, R. et al. · EClinicalMedicine (2020)

212 cited
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: A randomized controlled trial

Ross, S., Bossis, A. P., Guss, J. et al. · Journal of Psychopharmacology (2016)

Positive effects of psychedelics on depression and wellbeing scores in individuals reporting an eating disorder

Spriggs, M. J., Kettner, •. H., Carhart-Harris, •. R. L. · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity (2020)

Survey study of challenging experiences after ingesting psilocybin mushrooms: Acute and enduring positive and negative consequences

Carbonaro, T. M., Bradstreet, M. P., Barrett, F. S. et al. · Journal of Psychopharmacology (2016)

The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects

Olson, D. E. · ACS Pharmacology and Translational Science (2020)

Show all 55 references
Quality of acute psychedelic experience predicts therapeutic efficacy of psilocybin for treatment-resistant depression

Roseman, L., Nutt, D. J., Carhart-Harris, R. L. · Frontiers in Pharmacology (2018)

The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects

Yaden, D. B., Griffiths, R. R. · ACS Pharmacology and Translational Science (2020)

Psychedelics and virtual reality: parallels and applications

Aday, J. S., Davoli, C. C., Bloesch, E. K. · Therapeutic Advances in Psychopharmacology (2020)

Psychedelics and the essential importance of context

Carhart-Harris, R. L., Roseman, L., Haijen, E. C. H. M. et al. · Journal of Psychopharmacology (2018)

Human hallucinogen research: guidelines for safety

Johnson, M. W., Richards, W. A., Griffiths, R. R. · Journal of Psychopharmacology (2008)

Use of Benefit Enhancement Strategies among 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) Users: Associations with Mystical, Challenging, and Enduring Effects

Lancelotta, R., Davis, A. K. · Journal of Psychoactive Drugs (2020)

Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects

Griffiths, R. R., Johnson, M. W., Richards, W. A. et al. · Psychopharmacology (2011)

Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects

Holze, F., Vizeli, P., Ley, L. et al. · Neuropsychopharmacology (2020)

192 cited
Intensity of Mystical Experiences Occasioned by 5-MeO-DMT and Comparison With a Prior Psilocybin Study

Barsuglia, J. P., Davis, A. K., Palmer, R. et al. · Frontiers in Psychology (2018)

Mystical Experiences in Retrospective Reports of First Times Using a Psychedelic in Finland

Kangaslampi, S., Hausen, A., Rauteenmaa, T. · Journal of Psychoactive Drugs (2020)

High dose psilocybin is associated with positive subjective effects in healthy volunteers

Nicholas, C. R., Henriquez, K. M., Gassman, M. C. et al. · Journal of Psychopharmacology (2018)

61 cited
Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later

Griffiths, R. R. · Journal of Psychopharmacology (2008)

Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors

Griffiths, R. R., Johnson, M. W., Richards, W. A. et al. · Journal of Psychopharmacology (2017)

393 cited
Ayahuasca dimethyltryptamine, and psychosis: a systematic review of human studies

Dos Santos, R. G., Hallak, J. E., Bouso, J. C. · Therapeutic Advances in Psychopharmacology (2017)

Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance

Griffiths, R. R., Richards, W. A., Mccann, U. et al. · Journal of Psychopharmacology (2006)

Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action

Vollenweider, F. X., Vollenweider-Scherpenhuyzen, M. F. I., Bäbler, A. et al. · NeuroReport (1998)

Long-term effects of psychedelic drugs: A systematic review

Aday, J. S., Mitzkovitz, C. M., Bloesch, E. K. et al. · Neuroscience and Biobehavioral Reviews (2020)

Prediction of psilocybin response in healthy volunteers

Studerus, E., Gamma, A., Kometer, M. et al. · PLOS ONE (2012)

Dose-response study of N,N-dimethyltryptamine in humans: subjective effects and preliminary results of a new rating scale

Strassman, R. J., Qualls, C. R., Uhlenhuth, E. H. et al. · JAMA Psychiatry (1994)

Self-reported negative outcomes of psilocybin users: A quantitative textual analysis

Bienemann, B., Ruschel, N. S., Campos, M. L. et al. · PLOS ONE (2020)

57 cited
Finding the self by losing the self: Neural correlates of ego-dissolution under psilocybin

Lebedev, A. V., L€ Ovd En, M., Rosenthal, G. et al. · Human Brain Mapping (2015)

Rostral Anterior Cingulate Thickness Predicts the Emotional Psilocybin Experience

Lewis, C. R., Preller, K. H., Braden, B. B. et al. · Biomedicines (2020)

24 cited
Replication and extension of a model predicting response to psilocybin

Russ, S. L., Carhart-Harris, R. L., Maruyama, G. et al. · Psychopharmacology (2019)

55 cited
States and traits related to the quality and consequences of psychedelic experiences

Russ, S. L., Carhart-Harris, R. L., Maruyama, G. et al. · Psychology of Consciousness Theory Research and Practice (2019)

Characterization and prediction of acute and sustained response to psychedelic psilocybin in a mindfulness group retreat

Smigielski, L., Kometer, M., Scheidegger, M. et al. · Scientific Reports (2019)

126 cited
Psilocybin-Assisted Group Therapy and Attachment: Observed Reduction in Attachment Anxiety and Influences of Attachment Insecurity on the Psilocybin Experience

Stauffer, C., Anderson, B. T., Ortigo, K. M. et al. · ACS Pharmacology and Translational Science (2020)

51 cited
Brain serotonin 2A receptor binding predicts subjective temporal and mystical effects of psilocybin in healthy humans

Stenbæk, D. S., Madsen, M. K., Ozenne, B. et al. · Journal of Psychopharmacology (2020)

LSD enhances suggestibility in healthy volunteers

Carhart-Harris, R. L., Kaelen, M., Whalley, M. G. et al. · Psychopharmacology (2014)

257 cited
A placebo-controlled investigation of synaesthesia-like experiences under LSD

Terhune, D. B., Luke, D. P., Kaelen, M. et al. · Neuropsychologia (2016)

43 cited
Acute effects of ayahuasca on neuropsychological performance: differences in executive function between experienced and occasional users

Bouso, J. C., Fábregas, J. M., Antonijoan, R. M. et al. · Psychopharmacology (2013)

Predicting responses to psychedelics: a prospective study

Haijen, E. C. H. M., Kaelen, M., Roseman, L. et al. · Frontiers in Pharmacology (2018)

339 cited
From Egoism to Ecoism: Psychedelics Increase Nature Relatedness in a State-Mediated and Context-Dependent Manner

Kettner, H., Gandy, S., Haijen, E. C. H. M. et al. · International Journal of Environmental Research and Public Health (2019)

131 cited
A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms

Uthaug, M. V., Lancelotta, R., van Oorsouw, K. et al. · Psychopharmacology (2019)

145 cited
Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution

Uthaug, M. V., Van Oorsouw, &. K., Kuypers, &. K. P. C. et al. · Psychopharmacology (2018)

Survey of subjective “God encounter experiences”: Comparisons among naturally occurring experiences and those occasioned by the classic psychedelics psilocybin, LSD, ayahuasca, or DMT

Griffiths, R. R., Hurwitz, E. S., Davis, A. K. et al. · PLOS ONE (2019)

171 cited
Pharmacokinetics of Escalating Doses of Oral Psilocybin in Healthy Adults

Brown, R. T., Nicholas, C. R., Cozzi, N. V. et al. · Clinical Pharmacokinetics (2017)

Pharmacokinetics and concentration-effect relationship of oral LSD in humans

Dolder, P. C., Schmid, Y., Haschke, M. et al. · International Journal of Neuropsychopharmacology (2015)

97 cited
Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects

Holze, F., Duthaler, U., Vizeli, P. et al. · British Journal of Clinical Pharmacology (2019)

Pivotal Mental States

Brouwer, A., Carhart-Harris, R. L. · Journal of Psychopharmacology (2020)

Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members

Santos, R. G., Landeira-Fernandez, J., Strassman, R. J. et al. · Journal of Ethnopharmacology (2007)

Reactions to psilocybin administered in a supportive environment

Leary, T., Litwin, G. H., Metzner, R. · Journal of Nervous and Mental Disease (1977)

The peak experience variable in DPT-assisted psychotherapy with cancer patients

Richards, W. A., Rhead, J. C., Dileo, F. B. et al. · Journal of Psychedelic Drugs (1997)

Set and setting, psychedelics and the placebo response: An extra-pharmacological perspective on psychopharmacology

Hartogsohn, I. · Journal of Psychopharmacology (2016)

Learning to Let Go: A Cognitive-Behavioral Model of How Psychedelic Therapy Promotes Acceptance

Wolff, M., Evens, R., Mertens, L. J. et al. · Frontiers in Psychiatry (2020)

A systematic study of microdosing psychedelics

Polito, V., Stevenson, R. J. · PLOS ONE (2019)

197 cited

Cited By (57)

Papers in Blossom that reference this study

Extended difficulties after psychedelic experiences: Prevalence and associations in a global, multilingual sample

Oliver, C. R., Luke, D., Evans, J. et al. · Research Square (2026)

Mystical Experience Induced by Esketamine Treatment: A Real-World Observational Study

Mallevays, M., Fuet, L., Danon, M. et al. · MedRvix (2026)

An open-label pilot study of psilocybin-assisted therapy for binge eating disorder

Dallery, J., Miller, J. L., Boissoneault, J. et al. · Journal of Eating Disorders (2026)

Predicting and exploring ayahuasca effects: Perception, mind-wandering, and EEG oscillations

Silva-Costa, N., Pessoa, J. A., Andrade, K. C. et al. · Journal of Psychopharmacology (2025)

Ayahuasca-assisted meaning reconstruction therapy as an early resource for bereavement: a non-randomized clinical trial

Soto-Angona, Ó., Andión, O., Sabucedo, P. et al. · Scientific Reports (2025)

Acute effects of psilocybin on the dynamics of gaze fixations during visual aesthetic perception

Muller, S., Cavanna, F., de la Fuente, L. A. et al. · Scientific Reports (2025)

On Minimizing Risk and Harm in the Use of Psychedelic

Evans, J., Aixalà, M., Anderson, B. T. et al. · Psychiatric Research & Clinical Practice (2025)

Major life changes following psychedelic use: A retrospective survey among people using psychedelics naturalistically

Aday, J. S., Glynos, N., Baker, A. et al. · Preprints (2024)

Strategies for resolving challenging psychedelic experiences: insights from a mixed-methods study

McAlpine, R., Kamboj, S. K. · Scientific Reports (2024)

Autonomic nervous system activity correlates with peak experiences induced by DMT and predicts increases in well-being

Bonnelle, V., Feilding, A., Rosas, F. E. et al. · Journal of Psychopharmacology (2024)

Show all 57 papers
Naturalistic psychedelic therapy: The role of relaxation and subjective drug effects in antidepressant response

Calder, A. E., Rausch, B., Liechti, M. E. et al. · Journal of Psychopharmacology (2024)

Pharmacological and non-pharmacological predictors of the LSD experience in healthy participants

Vizeli, P., Studerus, E., Holze, F. et al. · Translational Psychiatry (2024)

Personality traits explain the relationship between psychedelic use and less depression in a comparative study

Sjöström, D. K., Claesdotter-Knutsson, E., Kajonius, P. J. · Scientific Reports (2024)

The therapeutic alliance between study participants and intervention facilitators is associated with acute effects and clinical outcomes in a psilocybin-assisted therapy trial for major depressive disorder

Levin, A. W., Lancelotta, R., Sepeda, N. D. et al. · PLOS ONE (2024)

48 cited
Unique Psychological Mechanisms Underlying Psilocybin Therapy Versus Escitalopram Treatment in the Treatment of Major Depressive Disorder

Weiss, B., Leor Roseman, •., Giribaldi, B. et al. · International Journal of Mental Health and Addiction (2024)

Predicting the outcome of psilocybin treatment for depression from baseline fMRI functional connectivity

Copa, D., Erritzoe, D., Giribaldi, B. et al. · Journal of Affective Disorders (2024)

What Predicts Beneficial Outcomes in Psychedelic Use? A Quantitative Content Analysis of Psychedelic Health Outcomes

Acevedo, E. C., Uhler, S., White, K. et al. · Journal of Psychoactive Drugs (2024)

Patient perspectives and experiences with psilocybin treatment for treatment-resistant depression: a qualitative study

Breeksema, J. J., Niemeijer, A. R., Krediet, E. et al. · Scientific Reports (2024)

Effects of Ayahuasca on Gratitude and Relationships with Nature: A Prospective, Naturalistic Study

Aday, J. S., Bloesch, E. K., Davis, A. K. et al. · Journal of Psychoactive Drugs (2024)

15 cited
Who Are You After Psychedelics? A Systematic Review and a Meta-Analysis of the Magnitude of Long-Term Effects of Serotonergic Psychedelics on Cognition/Creativity, Emotional Processing and Personality

Solaja, I., Haldane, K., Mason, N. et al. · Neuroscience and Biobehavioral Reviews (2024)

Assessing expectancy and suggestibility in a trial of escitalopram v. psilocybin for depression

Szigeti, B., Weiss, B., Rosas, F. E. et al. · Psychological Medicine (2024)

Set and setting predict psychopathology, wellbeing and meaningfulness of psychedelic experiences: a correlational study

Borkel, L. F., Rojas-Hernández, J., Henríquez-Hernández, L. A. et al. · Expert Review of Clinical Pharmacology (2023)

Psychological and physiological effects of extended DMT

Luan, L. X., Eckernäs, E., Ashton, M. et al. · Journal of Psychopharmacology (2023)

Predicting the Intensity of Psychedelic-Induced Mystical and Challenging Experience in a Healthy Population: An Exploratory Post-Hoc Analysis

Carter, B., Cleare, A. J., Rucker, J. et al. · Neuropsychiatric Disease And Treatment (2023)

Case analysis of long-term negative psychological responses to psychedelics

Bremler, R., Katati, N., Shergill, P. et al. · Scientific Reports (2023)

Naturalistic psilocybin use is associated with persisting improvements in mental health and wellbeing: results from a prospective, longitudinal survey

Nayak, S., Jackson, H., Sepeda, N. D. et al. · Frontiers in Psychiatry (2023)

Predictors of psychedelic treatment outcomes among special operations forces veterans

Xin, Y., Armstrong, S. B., Averill, L. A. et al. · Psychology of Consciousness Theory Research and Practice (2023)

Assessing the risk of symptom worsening in psilocybin-assisted therapy for depression: a systematic review and individual participant data meta-analysis

Simonsson, O., Carhart-Harris, R., Davis, A. K. et al. · Psychiatry Research (2023)

Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences

Zeifman, R. J., Kettner, H., Pagni, B. A. et al. · Scientific Reports (2023)

22 cited
The Therapeutic Alliance in Psychedelic-Assisted Psychotherapy: A Novel Target for Research and Interventions

Kamilar-Britt, P., Gordis, E. B., Earleywine, M. · Psychedelic Medicine (2023)

Harnessing placebo: Lessons from psychedelic science

Pronovost-Morgan, C., Hartogsohn, I., Ramaekers, J. G. · Journal of Psychopharmacology (2023)

Assessment of the acute effects of 2C-B vs psilocybin on subjective experience, mood and cognition

Mallaroni, P., Mason, N. L., Reckweg, J. T. et al. · Clinical Pharmacology and Therapeutics (2023)

39 cited
Effects of ayahuasca on gratitude and relationships with nature: An open-label, naturalistic study

Bloesch, E. K., Davis, A. K., Domoff, S. E. et al. · Psyarxiv (2023)

Personality change in a trial of psilocybin therapy v. escitalopram treatment for depression

Weiss, B., Ginige, I., Shannon, L. et al. · Psychological Medicine (2023)

The Canadian Psychedelic Survey: Characteristics, Patterns of Use, and Access in a Large Sample of People Who Use Psychedelic Drugs

Lake, S., Lucas, P. · Psychedelic Medicine (2023)

Personal Psychedelic Use Is Common Among a Sample of Psychedelic Therapists: Implications for Research and Practice

Aday, J. S., Skiles, Z., Eaton, N. et al. · Psychedelic Medicine (2023)

Investigation of self-treatment with lysergic acid diethylamide and psilocybin mushrooms: Findings from the Global Drug Survey 2020

Kopra, E., Ferris, J. A., Winstock, A. R. et al. · Journal of Psychopharmacology (2023)

Psychedelic replications in virtual reality and their potential as a therapeutic instrument: an open-label feasibility study

Kaup, K. K., Vasser, M., Tulver, K. et al. · Frontiers in Psychiatry (2023)

Reduced death anxiety as a mediator of the relationship between acute subjective effects of psychedelics and improved subjective well-being

Moreton, S. G., Arena, A. F., Foy, Y. et al. · Death Studies (2023)

A neurophenomenological approach to non-ordinary states of consciousness: hypnosis, meditation, and psychedelics

Timmermann, C., Vollenweider, F. X. · Trends in Cognitive Sciences (2023)

Optimizing outcomes in psilocybin therapy: Considerations in participant evaluation and preparation

Modlin, N. L., Miller, T. M., Rucker, J. J. et al. · Journal of Affective Disorders (2023)

Scoping Review of Experiential Measures from Psychedelic Research and Clinical Trials

Herrmann, Z., Earleywine, M., De Leo, J. et al. · Journal of Psychoactive Drugs (2022)

Neural Mechanisms and Psychology of Psychedelic Ego Dissolution

Stoliker, D., Egan, G. F., Friston, K. J. et al. · Pharmacological Reviews (2022)

Adverse events in clinical treatments with serotonergic psychedelics and MDMA: A mixed-methods systematic review

Breeksema, J. J., Kuin, B. W., Kamphuis, J. et al. · Journal of Psychopharmacology (2022)

Comparison of psychedelic and near-death or other non-ordinary experiences in changing attitudes about death and dying

Swee, M. B., Nayak, S., Hurwitz, E. et al. · PLOS ONE (2022)

Antidepressant effects of a psychedelic experience in a large prospective naturalistic sample

Nygart, V., Pommerencke, L. M., Haijen, E. et al. · Journal of Psychopharmacology (2022)

46 cited
Pattern Breaking: A Complex Systems Approach to Psychedelic Medicine

Hipólito, I., Mago, J., Rosas, F. E. et al. · Psyarxiv (2022)

Adverse experiences resulting in emergency medical treatment seeking following the use of magic mushrooms

Kopra, E., Ferris, J. A., Winstock, A. R. et al. · Journal of Psychopharmacology (2022)

Predictors and potentiators of psychedelic-occasioned mystical experiences

Gandy, S. · Journal of Psychedelic Studies (2022)

Psilocybin-Induced Mystical-Type Experiences are Related to Persisting Positive Effects: A Quantitative and Qualitative Report

McCulloch, D. E-W., Madsen, M. K., Jensen, P. S. et al. · Frontiers in Pharmacology (2022)

79 cited
Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT

Barker, S. A. · Psychopharmacology (2022)

43 cited
Great Expectations: Recommendations for improving the methodological rigor of psychedelic clinical trials

Aday, J. S., Heifets, B. D., Pratscher, S. D. et al. · Psychopharmacology (2021)

“Meeting the Medicine Halfway”: Ayahuasca Ceremony Leaders’ Perspectives on Preparation and Integration Practices for Participants

Callon, C., Williams, M., Lafrance, A. · Journal of Humanistic Psychology (2021)

Safer Tripping: Serotonergic Psychedelics and Drug Checking. Submission and Detection Rates, Potential Harms, and Challenges for Drug Analysis

Hirschfeld, T., Smit-Rigter, L., Van Der Gouwe, D. et al. · Current Addiction Reports (2021)

Recreation and Realization: Reported Motivations of Use Among Persons Who Consume Psychedelics in Non-Clinical Settings

Dollar, C. B. · Qualitative Criminology (2021)

The Promise of Psychedelic Science

Olson, D. E. · ACS Pharmacology and Translational Science (2021)

Baseline power of theta oscillations predicts mystical-type experiences induced by DMT in a natural setting

Tagliazucchi, E., Zamberlan, F., Cavanna, F. et al. · Frontiers in Psychiatry (2021)

Your Personal Research Library

Go Pro to save papers, add notes, rate studies, and organize your research into custom shelves.

See Pro PlansSign in