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Academic Journal

ACS Pharmacology and Translational Science

26 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Assessing the Potential Cardiovascular Risk of Microdosing the Psychedelic LSD in Mice

Chronic administration of sub‑hallucinogenic (microdose) LSD in mice produced no ventricular thickening or other ECG-detected cardiotoxic changes, whereas serotonin (positive control) caused significant ventricular thickening. In vitro assays showed similar 5‑HT2B affinity across mouse and human receptors and that low‑dose LSD yields only transient 5‑HT2B activation compared with the cardiotoxin d‑fenfluramine, together providing no evidence of cardiovascular risk from prolonged low‑dose LSD in this mouse model.

Published
Journal
ACS Pharmacology and Translational Science
Authors
Effinger, D. P., Schalk, S. S., King, J. L., Wallingford, J. R., O'connell, C. K., Calderon, J. R., Kopecky, B. J., Mccorvy, J. D., Thompson, S. M.
Open Accessindividual

5-Methoxy-2-aminoindane Reverses Diet-Induced Obesity and Improves Metabolic Parameters in Mice: A Potential New Class of Antiobesity Therapeutics

This mouse model study examines the metabolic efficacy of the psychoactive aminoindane derivative MEAI on diet-induced obesity (DIO). MEAI treatment significantly reduced overweight and adiposity, improved glycemic control, decreased hepatic lipid accumulation, increased energy expenditure and fat utilization, and normalized voluntary locomotion without overstimulatory effects, suggesting its potential as a novel therapeutic approach for obesity and related metabolic disorders.

Published
Journal
ACS Pharmacology and Translational Science
Authors
Baraghithy, S., Gammal, A., Permyakova, A., Hamad, S., Kocvarová, R., Calles, Y., Tam, J.
Open Accessindividual

Serotonin-2 Receptor Agonists Produce Anti-inflammatory Effects through Functionally Selective Mechanisms That Involve the Suppression of Disease-Induced Arginase 1 Expression

This in vitro study examines functional selectivity between two 5-HT2A receptor agonists, (R)-2,5-dimethoxy-4-iodoamphetamine [(R)-DOI] and (R)-2,5-dimethoxy-4-trifluoromethylamphetamine [(R)-DOTFM], in the context of their impact on inflammation and airway hyperresponsiveness (AHR) in a murine asthma model. Despite similar in vitro activity and behavioral potency, (R)-DOTFM does not prevent inflammation or elevated AHR, in contrast to (R)-DOI, suggesting distinct anti-inflammatory mechanisms associated with certain psychedelics.

Published
Journal
ACS Pharmacology and Translational Science
Authors
Flanagan, T. W., Foster, T. P., Galbato, T. E., Lum, Y., Louie, B., Song, G., Halberstadt, A. L., Billac, G. B., Nichols, C. D.
Open Accessindividual

The Psychedelic N,N-Dipropyltryptamine Prevents Seizures in a Mouse Model of Fragile X Syndrome via a Mechanism that Appears Independent of Serotonin and Sigma1 Receptors

This mouse study investigated the effects of N,N-dipropyltryptamine (DPT), a psychedelic tryptamine, on audiogenic seizures in a mouse model of fragile X syndrome (genetic cause of autism). DPT was found to prevent seizures at a 10 mg/kg dose completely but not at lower doses (3 or 5.6 mg/kg). Despite being a serotonin receptor agonist, the antiepileptic effects of DPT were not mediated through specific serotonin receptor subtypes (5-HT2A, 5-HT1B, or 5-HT1A), nor through sigma1 receptors.

Published
Journal
ACS Pharmacology and Translational Science
Authors
Tyagi, R., Saraf, T. S., Canal, C. E.
Open Accessmeta

Working with Weirdness: A Response to “Moving Past Mysticism in Psychedelic Science”

This commentary (2021) argues against the removal of the mystical experience concept from psychedelic science, advocating instead for a research approach that embraces the variability and subjective depth of these experiences. The authors contend that acknowledging these transformative states is essential for understanding the therapeutic potential of psychedelics rather than relying solely on neurobiological explanations.

Published
Journal
ACS Pharmacology and Translational Science
Authors
Breeksema, J. J., van Elk, M.
Open Accessindividual

Reconciling Mystical Experiences with Naturalistic Psychedelic Science: Reply to Sanders and Zijlmans

This commentary (2021) offers a rebuttal to the opinion piece on Moving Past Mysticism in Psychedelic Science by Sanders and Zijlmans and argues against the notion of demystifying psychedelic experiences or dismissing mystical experiences from the scope of empirical inquiry. Given that all experiences are ineffable by the nature of their subjectivity, it is argued that the epistemic gap between subjective and objective viewpoints of consciousness is a question of philosophy and that it is not the role of science to decide whether metaphysical insights related to mystical experiences are compatible with their particular worldview.

Published
Journal
ACS Pharmacology and Translational Science
Authors
Jylkkä, J.

Quick Facts

Papers Indexed
26
h-Index
43
Open Access
No
Publisher
American Chemical Society
Country
United States
Website
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