ACS Pharmacology and Translational Science

Working with Weirdness: A Response to “Moving Past Mysticism in Psychedelic Science”

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Breeksema, J. J., van Elk, M.

This commentary (2021) argues against the removal of the mystical experience concept from psychedelic science, advocating instead for a research approach that embraces the variability and subjective depth of these experiences. The authors contend that acknowledging these transformative states is essential for understanding the therapeutic potential of psychedelics rather than relying solely on neurobiological explanations.

Abstract

In response to a recent call to rid psychedelic science of the concept of mystical experience, we argue that acknowledging the varieties and weirdness of psychedelic experiences should be at the heart of any research program on this topic. We highlight the rich tradition and scientific tools for studying mystical-type experiences, their relevance for understanding the therapeutic effects of psychedelics, as well as the need for more diversity in the experiences and participants included in this research.