This commentary (2018) proposes a theoretical model wherein 5-HT2A receptor stimulation-the primary mechanism of psychedelics-relaxes prior beliefs and heightens sensitivity to context, contrasting with the stabilising role of the 5-HT1A receptor. It suggests that this mechanism facilitates effective therapeutic change by enabling the revision of rigid assumptions and behaviours during periods of uncertainty.
- Published
- Journal
- World Psychiatry
- Authors
- Carhart-Harris, R. L.