This secondary analysis of an RCT comparing psilocybin therapy to escitalopram in MDD patients (n=59) found that psilocybin produced superior improvements in cognitive biases. Psilocybin significantly increased self-reported optimism (d=1.1) and optimistic beliefs about desirable life events (d=1.1), while improving all three domains of dysfunctional attitudes (achievement, dependency, and self-control). Escitalopram showed more modest effects, reducing pessimism about negative events and improving only the achievement domain of dysfunctional attitudes.
- Published
- Journal
- European Neuropsychopharmacology
- Authors
- Henry, J., Giribaldi, B., Nutt, D. J., Erritzoe, D., Carhart-Harris, R., Lyons, T.