Outcome MeasureDepression

HAM-D6

Hamilton Depression Rating Scale – 6-item subscale

2 Papers in Blossom

Outcome Data Across Studies

Reported results for HAM-D6 across 1 study with quantitative data.

Outcome data across 1 study arm–timepoint observations
SD
Factors Associated with Antidepressant Effects of Ketamine: A Reanalysis of Double-Blind Randomized Placebo-Controlled Trial of Intravenous Ketamine for Treatment-Resistant Depression
2023Primary
Therapeutic-dose ketamine subset (0.5 + 1.0 mg/kg)(experimental)3316.84.3—

Papers Using HAM-D6

Open Accessindividual

Factors Associated with Antidepressant Effects of Ketamine: A Reanalysis of Double-Blind Randomized Placebo-Controlled Trial of Intravenous Ketamine for Treatment-Resistant Depression

Reanalysis of a placebo‑controlled double‑blind RCT of intravenous ketamine in 31 adults with treatment‑resistant depression found that later age of depression onset predicted a greater antidepressant response three days after infusion, whereas age, sex, baseline severity and dissociative scores showed no association. The authors propose that impaired glutamatergic signalling and reduced neuroplasticity in earlier‑onset cases may explain the diminished ketamine response.

Published
Journal
Pharmacopsychiatry
Authors
Yonezawa, K., Uchida, H., Yatomi, T., Ohtani, Y., Nomoto-Takahashi, K., Nakajima, S., Mimura, M., Tani, H., Ac, A.
Open Accessindividual

Efficacy of intravenous ketamine treatment in anxious versus nonanxious unipolar treatment-resistant depression

This multisite, double-blind, placebo-controlled study (n=99) evaluated the effect of ketamine (3.5 -; 35 mg/70kg) versus midazolam (3.15 mg/70kg) in anxious versus non-anxious unipolar treatment-resistant depression (TRD). The pilot results concluded that there was no significant effect found between both groups. In contrast to traditional antidepressants, the effects of ketamine may be similar in both anxious and non-anxious TRD subjects.

Published
Journal
Depression and Anxiety
Authors
Salloum, N. C., Fava, M., Freeman, M. P., Flynn, M., Hoeppner, B., Hock, R. S., Cusin, C., Iosifescu, D. V., Trivedi, M. H., Sanacora, G., Mathew, S. J., Debattista, C., Ionescu, D. F., Papakostas, G. I.

Quick Facts

Full Name
Hamilton Depression Rating Scale – 6-item subscale
Domain
Depression
Papers Indexed
2
Score Range
0–22
Interpretation
Lower = better
Unit
points
All Measures