LSDPsilocybin

Common neural signatures of psychedelics: frequency-specific energy changes and repertoire expansion revealed using connectome-harmonic decomposition

This academic book chapter (2018) uses the new concepts of connectome harmonics and connectome-harmonic decomposition to describe the brain activity associated with the psychedelic state. A heightened state of criticality on both LSD and psilocybin is observed.

Authors

  • Atasoy, S.
  • Carhart-Harris, R. L.
  • Deco, G.

Published

Progress in Brain Research
individual Study

Abstract

The search for the universal laws of human brain function is still on-going but progress is being made. Here we describe the novel concepts of connectome harmonics and connectome-harmonic decomposition, which can be used to characterize the brain activity associated with any mental state. We use this new frequency-specific language to describe the brain activity elicited by psilocybin and LSD and find remarkably similar effects in terms of increases in total energy and power, as well as frequency-specific energy changes and repertoire expansion. In addition, we find enhanced signatures of criticality suggesting that the brain dynamics tune toward criticality in both psychedelic elicited states. Overall, our findings provide new evidence for the remarkable ability of psychedelics to change the spatiotemporal dynamics of the human brain.

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Research Summary of 'Common neural signatures of psychedelics: frequency-specific energy changes and repertoire expansion revealed using connectome-harmonic decomposition'

Study Details

Cited By (12)

Papers in Blossom that reference this study

N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences

Atasoy, S., Carhart-Harris, R. L., Deco, G. et al. · Neuropsychopharmacology (2025)

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Carhart-Harris, R. L., Deco, G., Erritzoe, D. et al. · Annals of the New York Academy of Sciences (2025)

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Atasoy, S., Cabral, J., Carhart-Harris, R. L. et al. · National Science Review (2024)

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Argento, E., Brendle, M., Girn, M. et al. · Journal of Psychopharmacology (2024)

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Carhart-Harris, R. L., Castro-Rodrigues, P., Erritzoe, D. et al. · Nature Mental Health (2024)

Distributed harmonic patterns of structure-function dependence orchestrate human consciousness

Adapa, R., Allanson, J., Atasoy, S. et al. · Communications Biology (2023)

Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape

Carhart-Harris, R. L., Cruzat, J., Deco, G. et al. · Nature Communications (2022)

Effects of classic psychedelic drugs on turbulent signatures in brain dynamics

Carhart-Harris, R. L., Cruzat, J., Deco, G. et al. · Network Neuroscience (2022)

19 cited
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Carhart-Harris, R. L., Luppi, A. I., Menon, D. K. et al. · NeuroImage (2021)

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Ketamine and Serotonergic Psychedelics: Common Mechanisms Underlying the Effects of Rapid-Acting Antidepressants

Gilbert, J. R., Greenwald, M., Henter, I. D. et al. · International Journal of Neuropsychopharmacology (2020)

Show all 12 papers
Updating the dynamic framework of thought: Creativity and psychedelics

Carhart-Harris, R. L., Christoff, K., Girn, M. et al. · NeuroImage (2020)

Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin

Atasoy, S., Cabral, J., Carhart-Harris, R. L. et al. · NeuroImage (2019)

183 cited

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