Effects of mescaline and lysergic acid (d-LSD-25)
Cattell, J. P., Hoch, P. H., Pennes, H. H.
This early clinical study (1952) investigated the effects of mescaline (0.4 -; 0.6g) and LSD (10-120μg) in patients with schizophrenia (n=59 & 21) and found that it aggravated their symptoms and made their psychic integration even more disorganized compared to healthy individuals.
Abstract
Methods: The effects of mescaline and lysergic acid were studied in schizophrenic patients.Results: It was found that physiological changes were produced in these patients and that their mental symptomatology was markedly aggravated.Discussion: The observations made with the above-mentioned drugs on normal individuals were compared with those seen in schizophrenic patients. Mescaline and lysergic acid are drugs that disorganize the psychic integration of a person. This disorganization is much more apparent in schizophrenics than in normals. The diagnostic, prognostic, and therapeutic use of these drugs is also discussed.