•Neuron
Ketamine: A Paradigm Shift for Depression Research and Treatment
open
Abdallah, C. G., Charney, D. S., Duman, R. S., Krystal, J. H., Sanacora, G.
This review and perspective paper (2019) gives a high-level overview of what we know about ketamine's effects and how it has changed our perspective on (the treatment of) depression.
Abstract
Ketamine is the first exemplar of a rapid-acting antidepressant with efficacy for treatment-resistant symptoms of mood disorders. Its discovery emerged from a reconceptualization of the biology of depression. Neurobiological insights into ketamine efficacy shed new light on the mechanisms underlying antidepressant efficacy.