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Academic Journal

Neuron

5 Papers Indexed in Blossom

Published Papers

Paywallindividual

The polypharmacology of psychedelics reveals multiple targets for potential therapeutics

This receptor profiling study (n=41 compounds) maps the pharmacological activity of classical psychedelics across 318 human G-protein-coupled receptors and, for LSD, over 450 human kinases. It finds that psychedelics act potently at nearly all serotonin, dopamine, and adrenergic receptors, with multiple 5-HT2A receptor signalling pathways linked to psychedelic effects in vivo.

Published
Journal
Neuron
Authors
Jain, M. K., Gumpper, R. H., Slocum, S. T., Gloriam, D. E., Nichols, D. E., Roth, B. L., Schmitz, G. P., Madsen, J. S., Tummino, T. A., Suomivuori, C. M., Huang, X. P., Shub, L., Diberto, J. F., Kim, K., Deleon, C., Krumm, B. E., Fay, J. F., Keiser, M., Hauser, A. S., Dror, R. O., Shoichet, B.
Paywallindividual

Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD

This study inspects how LSD binds to the 5-HT2B (serotonin 2B) receptor (not the 2A receptor most commonly studied) to understand what signalling cascades it triggers. The researchers determined the cryo-EM structures of LSD-bound HTR2B in the transducer-free, Gq-protein-coupled, and β-arrestin-1-coupled states. The information from this study can help with the design of novel psychedelics.

Published
Journal
Neuron
Authors
Cao, C., Barros-Álvarez, X., Kim, K., Dämgen, M. A., Panova, O., Suomivuori, C-M., Fay, J. F., Zhong, X., Krumm, B. E., Gumpper, R. H., Seven, A. B., Robertson, M. J., Krogan, N. J., Hüttenhain, R., Nichols, D. E., Dror, R. O., Skiniotis, G., Roth, B. L.
Open Accessindividual

Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

This cell study shows that brain cells, specifically the layer five pyramidal neurons in mice, grew by 10% after the introduction of psilocybin. The effects were still present 30 days later, providing more evidence for brain plasticity as an underlying mechanism of psychedelic-assisted therapies' long-lasting effects.

Published
Journal
Neuron
Authors
Shao, L-X,, Liao, C., Gregg, I., Savalia, N., Delagarza, K., Kwan, A. C.
Open Accessmeta

Ketamine: A Paradigm Shift for Depression Research and Treatment

This review and perspective paper (2019) gives a high-level overview of what we know about ketamine's effects and how it has changed our perspective on (the treatment of) depression.

Published
Journal
Neuron
Authors
Abdallah, C. G., Charney, D. S., Duman, R. S., Krystal, J. H., Sanacora, G.
Open Accessindividual

Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior

This study (2007) identifies the biological reasons, the specific regulation of Gi/o proteins and Src, why psychedelics that affect the 5-HT2A receptor have hallucinogenic effects while agonists (lusuride) do not.

Published
Journal
Neuron
Authors
Gonza ´lez-Maeso, J., Weisstaub, N. V., Zhou, M., Chan, P., Ivic, L., Ang, R., Lira, A., Bradley-Moore, M., Ge, Y., Zhou, Q., Sealfon, S. C., Gingrich, J. A.

Quick Facts

Papers Indexed
5
h-Index
548
Open Access
No
Publisher
Elsevier
Country
United States
Website
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