Long-term benefits of single-dose psilocybin in depressed patients with cancer
Agrawal, M., Emanuel, E., Jenkins, B., Leeks, C., Roddy, K.
This Phase II trial long-term follow-up (n=30) found that a single dose of psilocybin (25mg) combined with psychological support provided sustained benefits for cancer patients with depression, with 54% showing significant depression reduction (50% remission) and 46% experiencing reduced anxiety at 2 years' follow-up, suggesting a potential paradigm shift in depression treatment for cancer patients compared to traditional daily antidepressants.
Abstract
Background: Patients with cancer often struggle with depression, which can negatively impact quality of life as well as be challenging to manage.Methods: A phase 2 trial was conducted that demonstrated safety, feasibility, and efficacy of a single dose of psilocybin combined with psychological support in a community cancer setting in 30 patients with cancer and a major depressive disorder. Here, efficacy outcomes at 2 years’ follow-up are reported.Results: Of 28 patients, 15 (53.6%) demonstrated significant reduction in depression as measured by the Montgomery Asberg Depression Rating Scale (average, -15.0 points from baseline; p < .001), and 14 (50%) had sustained depression reduction. Thirteen patients (46.4%) experienced significant reduction in anxiety as measured by the Hamilton Anxiety Rating Scale (average, -13.9 points from baseline, p < .001), and 12 (42.9%) had sustained anxiety reduction.Conclusions: These findings demonstrate robust antidepressive activity from a single 25 mg dose of psilocybin combined with psychotherapy and suggest a potentially paradigm-changing alternative to traditional antidepressants requiring further study.