In a phase 2 open‑label trial, a single 25 mg dose of psilocybin given in a group therapy setting with one‑to‑one therapist support was safe and feasible in 30 patients with cancer and major depressive disorder, with no psilocybin‑related serious adverse events. The treatment produced a large reduction in depressive symptoms (mean 19.1‑point decrease; 80% sustained response; 50% remission at week 1 maintained through 8 weeks), suggesting clinical efficacy warranting further study.
- Published
- Journal
- Cancer
- Authors
- Agrawal, M., Ameli, R., Bates, M., Beaussant, Y., Honstein, H., Jenkins, B., Richards, B. D., Richards, W. A., Roddy, K., Schor, N., Shnayder, S., Stevens, N., Thambi, P.