Mental changes experimentally produced by d-lysergic acid diethylamide tartrate
Deshon, H. J., Rinkel. M., Solomon, H. C.
This early open-label investigation (1952) reports observations of mental changes in normal adults (n=15) produced by LSD (70μg/70kg) across 17 repeated experiments. Alterations were observed in the areas of thinking and speech, emotion, mood and affect, sensory and time perception, behavior, morbid ideas, and sensory experiences, and neurological signs, which were taken to reflect a schizophrenic-like state.
Abstract
Results: L.S.D. (Lyserg Saure Diäthylamide) produced mental changes in 15 normal adults. There were alterations in thinking, speech, emotion, mood and affect, sensory and time perception, and neurological signs. The L.S.D. reaction showed aspects of a toxic picture and simulation of schizophrenic reactions. Schizo-affective and manic-like states were also encountered. Cathartic ventilation was seen in only one patient.Discussion: Clinical effects of LSD imply involvement of higher and perhaps lower levels of the central nervous system.