Possible Interactions Between 5-HT2A Receptors and the Endocannabinoid System in Humans: Preliminary Evidence of Interactive Effects of Ayahuasca and Endocannabinoids in a Healthy Human Subject

Crippa, J. A., Dos Santos, R. G., Hallak, J. E., Marchioni, C., Osório, F. L., Queiroz, M. E. C., Rocha, J. M., Rossi, G. N., Silveira, G., Yonamine, M.

This open-label case study (n=1) investigated the effects of a single oral dose of ayahuasca (49.14mg DMT, 124.88mg harmine,54.6mg tetrahydroharmine, and 2.73mg harmaline /70kg) and observed a continuous decrease in the plasma level of the endocannabinoid anandamide and late-stage increase of the endocannabinoid 2-arachidonoylglycerol.