This survey study (n=121) explored the co-occurrence of PTSD in patients with a substance use disorder (SUD). It was found that SUD patients with PTSD were more likely to use MDMA than those without PTSD and MDMA use was associated with avoidance symptoms. The authors conclude that MDMA use might reflect an attempt to self-medicate to deal with avoidance symptoms however, it may also be the case that MDMA use led to more severe avoidance symptoms.
Background
Adolescent patients with a substance use disorder (SUD) often fulfil the criteria for a co-occurring post-traumatic stress disorder (PTSD). However, it is not clear if these dual-diagnosed adolescents present with unique levels of substance use and how their substance use relates to PTSD symptom clusters.
Objective
To investigate substance use in adolescents with co-occurring PTSD and SUD. Additionally, we explored how the use of specific substances is related to specific PTSD symptom clusters.
Method
We recruited n = 121 German adolescent SUD patients, in three groups: no history of traumatic events (TEs) (n = 35), TEs but not PTSD (n = 48), probable PTSD (n = 38). All groups were administered a trauma questionnaire and were asked to report their past-month substance use.
Results
Adolescents with probable PTSD and SUD report a higher frequency of MDMA use than adolescents with no PTSD and no TE (PTSD vs. no TE: U = 510.5, p = .016; PTSD vs. TE: U = 710.0, p = .010). The use of MDMA was more frequent in adolescents with avoidance symptoms (X2 (1) = 6.0, p = .014). Participants report using substances at a younger age (PTSD vs. no TE: U = 372.0, p = .001; PTSD vs. TE: U = 653.5, p = .022) and PTSD symptom onset was on average 2.2 years earlier than first MDMA use (t (26) = −2.89, p = .008).
Conclusions
Adolescent SUD patients with probable PTSD are more likely to use MDMA than SUD patients without PTSD. The use of MDMA was associated with reported avoidance symptoms. The first age of MDMA use is initiated after PTSD onset. It is unclear whether the association of MDMA use with avoidance symptoms is due to efforts to reduce these symptoms or a result of regular MDMA use.
Papers cited by this study that are also in Blossom
Carlyle, M., Stevens, T., Fawaz, L. et al. · Journal of Psychopharmacology (2019)
Kuypers, K. P. C., Ramaekers, J. G. · Journal of Psychopharmacology (2005)
Mitchell, J., Bogenschutz, M. P., Lilienstein, A. et al. · Nature Medicine (2021)
Papaseit, E., Pérez-Mañá, C., Mateus, J. A. et al. · Neuropsychopharmacology (2016)
Lukas and colleagues situate their study in the context of frequent co-occurrence between post-traumatic stress disorder (PTSD) and substance use disorders (SUDs) in adolescents, noting that 20–54% of adolescent SUD patients may meet PTSD criteria while about 30% of adolescent PTSD patients present with SUD. They outline three explanatory frameworks for this co-occurrence: shared genetic or environmental risk, increased exposure to traumatic events (TEs) via high‑risk behaviour, and the self‑medication hypothesis in which PTSD symptoms precede and motivate substance use. The authors note that prior work has established greater SUD severity in adolescents with co-occurring PTSD, but that little is known about the use of specific substances in relation to specific PTSD symptom clusters (intrusion, avoidance, hyperarousal) in this age group. This cross‑sectional exploratory study therefore set out to compare past‑month substance use frequencies across three subgroups of treatment‑seeking adolescent SUD patients — those without trauma exposure (NoTE), those with trauma exposure but not PTSD (TE), and those with probable PTSD — and to examine whether use of particular substances relates to the three PTSD symptom clusters. A secondary aim was to compare ages of first substance use across groups and to test whether onset of PTSD symptoms preceded first use of particular substances, as predicted by the self‑medication hypothesis.
The study used a cross‑sectional design embedded in routine diagnostic procedures at a German outpatient clinic for adolescent substance abuse. Between November 2017 and November 2020, 234 treatment‑seeking adolescents consented; the analytic sample comprised n = 121 participants (42% female) who completed the required questionnaires. Participants were assigned to three groups based on self‑report on the UCLA PTSD Reaction Index for DSM‑IV (German version): NoTE (no reported traumatic event), TE (reported TE but did not meet PTSD criteria), and PTSD (probable PTSD when Criterion A plus intrusion, avoidance and hyperarousal criteria were all met). Internal consistency of the UCLA subscales was reported as good to acceptable (α = .82 and .81 for Criteria A and C; α = .77 and .76 for B and D). Substance use was assessed by clinical psychologists using a study‑specific interview that recorded the number of days each substance was used in the past month and the age of first use. The substances with data analysed were tobacco, alcohol, cannabis, MDMA, and amphetamine ('speed'); methamphetamine, cocaine, opioids, benzodiazepines and solvents were excluded from frequency analyses because of very low or zero reported past‑month use. Diagnostic status for SUD was evaluated with the MINI‑KID (DSM‑5 criteria). Caregivers provided sociodemographic information including age, gender, education (ISCED), and household income categories. Statistical analyses compared prevalence and frequency of substance use across the three groups. Chi‑square tests assessed prevalence differences, Kruskal‑Wallis tests assessed group differences on continuous substance frequency variables, and Mann‑Whitney U tests were used for pairwise follow‑ups when omnibus tests were significant. Within the TE and PTSD groups, Mann‑Whitney U tests examined associations between presence of each PTSD symptom cluster (intrusion, avoidance, hyperarousal) and substance use frequency. Six paired‑sample t‑tests compared age of PTSD symptom onset with age of first substance use. The significance threshold was α < 0.05, and the authors applied the Bonferroni‑Holm procedure to correct for multiple testing. Effect sizes were reported where applicable. The study procedures received institutional ethics approval and informed consent was obtained from participants and guardians.
The final sample included n = 121 adolescents. Group sizes are reported elsewhere in the extraction (PTSD n = 38, TE n = 48, NoTE n = 35 according to the abstract), and the three groups did not differ in distribution of SUD diagnoses, education level, or parental income. A significant difference across groups was observed in the proportion of female participants (X2(2) = 11.2, p = .004). No gender differences were detected for age of first substance use or past‑month use of the substances analysed. The most commonly reported trauma types were violence (26%) and sexual abuse (22%). Analyses of substance use identified MDMA as the substance that differed between groups. The proportion reporting past‑month MDMA use varied across groups (X2(2) = 10.60, p = .005, d = .62), with the probable PTSD group showing the highest prevalence. No group differences were found for past‑month tobacco, alcohol, cannabis or amphetamine use. Days of past‑month MDMA use also differed across groups (H(2) = 9.9, p = .007, η2 = .07); pairwise comparisons showed the PTSD group used MDMA more frequently than the NoTE group (U = 510.5, p = .016, η2 = .04) and the TE group (U = 710.0, p = .010, η2 = .04). The TE and NoTE groups did not differ in MDMA days (U = 839.5, p = .992). Within the TE and PTSD subgroups, MDMA use frequency was significantly higher among participants meeting the avoidance symptom‑cluster criterion than among those who did not (U = 7.68, p = .008, η2 = .73). No associations were detected between MDMA frequency and the intrusion or hyperarousal clusters. Regarding ages of onset, groups differed in age of first substance use (H(2) = 11.3, p = .003, η2 = .08); the PTSD group reported an earlier age of first use than the NoTE group (U = 372.0, p = .001, η2 = .14) and the TE group (U = 653.5, p = .022, η2 = .06). The authors also report that, on average, reported PTSD symptom onset preceded first MDMA use by about 2.2 years (t(26) = -2.89, p = .008), although they note that only a subset of participants could be included in these onset comparisons. Methamphetamine and several other substances were excluded from frequency analyses because of very low or absent past‑month reporting.
Lukas and colleagues interpret their findings as consistent with the self‑medication hypothesis in this sample of treatment‑seeking adolescents with SUD: adolescents with probable PTSD began substance use at an earlier age, were more likely to have used MDMA in the past month, and used it more frequently than peers without PTSD. The authors emphasise that MDMA use was particularly associated with the avoidance symptom cluster, and that reported PTSD symptom onset preceded initiation of MDMA use by an average of about two years in the subset analysed, which they view as further support for the notion that PTSD symptoms may motivate subsequent MDMA use. They discuss plausible mechanisms linking avoidance symptoms and MDMA: avoidance includes affective flattening and detachment, while MDMA can produce heightened empathy and prosocial feelings and is often used in social contexts, which might subjectively counter avoidance‑related distress. The authors also consider why MDMA was not associated with hyperarousal or intrusion: acute MDMA effects (sympathetic activation) could exacerbate hyperarousal, and MDMA‑related transient memory impairment might reduce intrusive memories. An alternative explanation raised is that regular MDMA use could worsen psychopathology — via neuropsychological effects, sleep disruption, depressive or psychotic‑like symptoms, withdrawal phenomena, or exposure to adulterated substances — and thereby contribute to development or worsening of PTSD symptoms. The authors compare their adolescent findings with adult literature that more often links alcohol, benzodiazepines or other substances with avoidance, and suggest developmental and contextual differences in adolescent substance use (different substance preferences and settings) may account for the discrepancy. They propose clinical implications: elevated MDMA use among adolescent SUD patients might signal untreated PTSD and clinicians should routinely assess whether substances are being used as self‑medication. The authors note several limitations they acknowledge: the cross‑sectional, retrospective design prevents causal inference; past‑month use reflects only a snapshot; reliance on self‑report may produce recall or desirability biases and may overestimate probable PTSD; small numbers limited some onset analyses; the convenience, treatment‑seeking sample limits generalisability beyond adolescent SUD patients; inability to control for sociodemographic confounders in primary non‑parametric analyses; and multiple testing risks despite Bonferroni‑Holm correction. They therefore recommend longitudinal and more comprehensive measurement in future research.
The authors conclude that, among adolescent treatment seekers with SUD, probable PTSD is associated with greater likelihood of past‑month MDMA use and higher frequency of MDMA use compared with peers without PTSD. This pattern may reflect self‑medication targeted at avoidance symptoms or, conversely, a contribution of MDMA use to worsening avoidance; regardless of directionality, clinicians should carefully assess for PTSD and for substance use that may function as self‑medication in this vulnerable population.
Approximately one-third of adults who fulfil the criteria for a psychiatric disorder also fulfil diagnostic criteria for at least one co-occurring psychiatric disorder (Forman-Hoffman, Batts, Hedden, Spagnola, & Bose, 2018). Co-occurring psychiatric disorders present a challenge for mental health professionals in inpatient settings, which is reflected by the increased length of stay and medical costs observed in patients with multiple such disorders compared to patients with only one. One such pattern of co-occurring disorders is the co-occurrence of post-traumatic stress disorder (PTSD) and substance use disorders (SUDs). This cooccurrence is frequently observed in adolescents, with 20-54% of adolescent SUD patients fulfiling PTSD criteria. On the other hand, 30% of adolescent PTSD patients present with SUD. The co-occurrence of PTSD and SUD in adolescents is associated with increased SUD severity, and often presents a situation that makes therapeutic care more challenging, i.e. through PTSD-associated flashbacks serving as a trigger for increased substance use. While a number of possible explanations exist for this pattern of co-occurrence, three major hypotheses have emerged: i) SUD and PTSD may result from a common risk factor. Previous research has shown that both disorders have similar genetic and environmental factors that increase the chance of their occurrence. ii) Adolescents who engage in substance use may generally engage in more frequent high-risk behaviours. This high-risk behavioural pattern may increase the chance of experiencing traumatic events (TEs), such as first-hand violence, and subsequently developing PTSD. iii) PTSD symptoms appear before a SUD is developed, and patients engage in substance use to cope with the PTSD symptoms, consequently developing a SUD. This self-medication hypothesis has gained much empirical supportshowing, for example, that one-fifth of PTSD patients use substances in an attempt to relieve PTSD symptoms such as hyperarousal, avoidance or intrusions. Per definition, the selfmedication hypothesis includes assumptions about the age of onset of PTSD and SUD namely, that SUD symptoms should develop following the PTSD symptoms. This pattern has been investigated and confirmed in previous studies, which showed that anxiety disorders, conduct disorders, and PTSDpredate future SUDs. Even though the severity of adolescent SUD has been associated with a co-occurring PTSD, little is known with regard to use of specific substances and PTSD symptomatology in adolescents. Based on the self-medication hypothesis, the specific subjective effects of different substances might be perceived as relieving symptoms, symptom neutral or leading to stronger symptoms. Accordingly, adolescents with SUD and PTSD might use different substances to achieve a subjective relief from different PTSD symptom clusters (SCs). Thus, a patient who experiences strong hyperarousal symptoms might show a preference for substances with a relaxing effect, e.g. benzodiazepines, while a patient with avoidance symptoms might prefer stimulating substances, e.g. amphetamine. Previous studies in adults investigating how the use of psychoactive substances relates to the presence of specific PTSD symptoms reported conflicting results. For instance, the presence of avoidance symptoms has been associated with alcohol, benzodiazepine, cocaine, and cannabis use. The question of specific substance use in a relation to distinct PTSD symptoms is particularly important for the development of targeted therapeutic interventions. However, no research so far could clarify these symptom-substance connections. Additionally, substance use and subsequent SUDs should have a later onset compared to the disorder that is medicated. This pattern has been shown previously for adult patients, but not for adolescents. Furthermore, it is unclear if TEs alone might already predispose adolescents to increased substance use and SUD severity. While an association of TEs with SUD has been repeatedly suggested, previous research from our group has found similar levels of SUD severity between adolescents with TEs but not PTSD and adolescents without TEs. It remains to be explored if similar differences are present concerning substance use. We conducted this cross-sectional, exploratory study with two aims The primary goal was to investigate differences in frequency of substance use between subgroups of adolescent SUD patients (with a history of TEs and PTSD, with TEs but without PTSD, with no trauma exposure) and to explore the relationships between substance use frequency and the three PTSD SCs (intrusion, hyperarousal, avoidance). The secondary goal was to explore differences in age of first substance use and if age of first substance use differed from the onset of PTSD symptoms. Although previous research showed differences in SUD severity between those three groups, the state of the literature did not support specific hypotheses regarding differences in substance use frequency.
Between November 2017 and November 2020, n = 234 treatment-seeking adolescents at a German outpatient clinic for adolescent substance abuse consented to participate in the study. From these participants, those who filled out the required questionnaires were selected, resulting in n = 121 (42% female) participants. These participants were divided into three groups based on whether they fulfilled PTSD criteria according to self-report ('PTSD'), reported a TE but did not fulfil PTSD criteria ('TE') or did not report any TE ('NoTE'). Detailed demographic information of the study sample can be found in Table.
The University of California at Los Angeles Post Traumatic Stress Disorder Reaction Index for DSM-IV (UCLA RI-IV), German version by, is a self-report questionnaire that screens for TEs and PTSD symptoms in adolescents. The instrument consists of a Criterion A section, in which patients select the TE that afflicts them the most from a list and indicate the traumatizing features of the event. The next section assesses the frequency of occurrence of PTSD symptoms during the past month (rated from 0 = none of the time to 4 = most of the time) and asks for the first age these symptoms were experienced with regard to the TE. The items map directly onto the DSM-IV intrusion (Criterion B), avoidance (Criterion C), and hyperarousal (Criterion D) SCs. Since the UCLA is a self-report questionnaire and does not include clinical judgment, we considered PTSD as probable and not as established, when all four criteria (Criterion A, B, C, & D) are present. Dependent variables (DVs) for this questionnaire were: age of first PTSD symptoms, probable presence of a PTSD, presence of a TE, and whether the criteria for the intrusion, avoidance, and hyperarousal SCs were fulfilled. In the current sample, internal consistency was good for criterion A and C (α = .82 and .81, respectively), and acceptable for criterion B and D (α = .77 and .76, respectively).
The extent of substance use was assessed by clinical psychologists via a self-designed interview, asking specifically for the number of days each substance was used in the past month and at which age they started using the substance. DVs from this assessment were days of past-month tobacco, alcohol, cannabis, methylenedioxymethamphetamine (MDMA), and amphetamine (specifically 'speed', but not methamphetamine, cocaine or other stimulants) use, as well as the age of first tobacco, alcohol, cannabis, MDMA, and amphetamine use.
The Mini-International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)is a diagnostic interview used to evaluate the presence of psychiatric disorders. The interview contains diagnostic questions to assess the presence of 32 psychiatric disorders according to DSM-5 criteria. The DV of interest was the presence of a SUD according to DSM-5 criteria.
The caregivers of our participants answered 36 questions from a self-designed questionnaire assessing socio-demographic data. We analysed the questions indicating age in years, gender, education level of the patient as well as yearly household income ('up to 10.000€', 'up to 20.000€', 'up to 30.000€', 'up to 45.000€', 'more than 45.000€'). Participants' educational levels were assessed according to the International Standard Classification of Education (ISCED) (UNESCO, 2012).
Data collection was embedded into the standard diagnostic procedures at our outpatient clinic. During the first appointment, the extent of past-year substance use was assessed, the questionnaires were handed out, and participants as well as legal guardians gave written informed consent to the study. The study was conducted in accordance with the Declaration of Helsinki. All procedures were approved by the Institutional Review Board of the University Hospital C. G. Carus Dresden (EK 66,022,018). Participants were not financially compensated for their contribution. For the assessment of differences in sociodemographic characteristics between the three groups, we performed chi-square tests on the proportion of male and female participants, educational achievement, parental income and type of SUD. Age differences were assessed via an analysis of variance.
For our main research question, we conducted chisquare tests to compare the prevalence of each substance across the three groups (noTE, TE, PTSD). Additionally, we performed a Kruskal-Wallis omnibus test to determine if our three groups differed in the five continuous DVs variables. If any of the omnibus comparisons was significant, we performed Mann-Whitney U follow-up tests between all three groups. We used three Mann-Whitney U tests, limited to the TE and PTSD groups, to analyse if the presence of the three SCs (intrusion, avoidance, hyperarousal) was associated with the use frequency of substances whose prevalence differed between the groups. For the analyses, related to our secondary research question we conducted a Kruskal-Wallis omnibus test and Mann-Whitney U follow-up tests to investigate group differences in age of substance use onset. Additionally, we performed six paired sample t-tests to compare age of PTSD symptom onset with age of first substance use. The level of significance was set to α < 0.05. To correct for Type 1 error through multiple testing we used the Bonferroni-Holm procedureto assess significance of the chi-square tests, the non-parametric tests (Kruskal-Wallis, Mann-Whitney U) and the paired samples t-tests. Wherever we report p-values, we report the adjusted Bonferroni-Holm threshold for statistical significance (α Bonferroni-Holm ) as well. Effect sizes were classified according to
The three groups did not differ in the distribution of SUD diagnoses, level of education, or parental income. Between the three groups only the proportion of female participants differed significantly (X 2 (2) = 11.2, p = .004, α Bonferroni-Holm = .006). The two gender groups did not differ in their age of first substance use (U = 1608.50, p = .199, α Bonferroni-Holm = .01) their past-month tobacco (U = 1554.5, p = .101, α Bonferroni-Holm = .008), alcohol (U = 1580.00, p = .259, α Bonferroni-Holm = .017), cannabis (U = 1558.00 p = .215, α Bonferroni-Holm = .013), MDMA (U = 1656.00, p = .285, α Bonferroni-Holm = .025), or amphetamine (U = 169.00, p = .419, α Bonferroni-Holm = .05) use. The types of traumas reported by our participants are displayed in Table. Most common were traumas related to violence (26%) and sexual abuse (22%).
We analysed differences in tobacco, alcohol, cannabis, MDMA, amphetamine use frequencies. While 13% of our sample fulfilled criteria for a methamphetamine use disorder, only n = 2 reported past-month use of methamphetamine, which is why we did not analyse methamphetamine use frequency. Furthermore, since none of our participants reported past-month use of cocaine, opioids, benzodiazepines or solvents we excluded these substances from the analyses as well. The proportion of participants who had used MDMA in the last month differed between groups (X 2 (2) = 10.60, p = .005, α Bonferroni-Holm = .010, d = .62) with the probable PTSD group reporting the highest proportion of past-month MDMA users. No difference in the use of other substances could be identified. Furthermore, across all three groups participants differed significantly in terms of the number of days of MDMA use in the last month (H (2) = 9.9, p = .007, α Bonferroni-Holm = .010, η 2 = .07). The PTSD group had a higher past month frequency of MDMA use than the noTE group (U = 510.5, p = .016, α Bonferroni-Holm = .025, η 2 = .04) and the TE group (U = 710.0, p = .010, α Bonferroni-Holm = .017, η 2 = .04). The TE group did not differ from the noTE group in days of MDMA use in the past month (U = 839.5, p = .992, α Bonferroni-Holm = .050, η 2 < .01). Both differences constitute small effects. Mean scores, proportions and complete test results are displayed in Table, median scores and interquartile range (IQR) can be found in Supplemental Table.
The past month frequency of MDMA use across the TE and PTSD groups was significantly higher in the group of participants fulfiling the avoidance criterion compared to those that did not (U = 7.68, p = .008, α Bonferroni-Holm = .017, η 2 = .73). For the other two SCs (intrusion, hyperarousal), no differences in frequency of MDMA use were detected, see Table. See Supplemental Tablefor median and IQR values.
Across all three groups participants differed significantly with medium-sized effects in terms of the age of their first substance use (H (2) = 11.3, p = .003, α Bonferroni-Holm = .008, η 2 = .08). The PTSD group had a lower age of first substance use than the noTE group (U = 372.0, p = .001, α Bonferroni-Holm = .025, η 2 = .14) and the TE group (U = 653.5, p = .022, α Bonferroni-Holm = .017, η 2 = .06), with the effect being
In this study, we aimed to investigate if adolescent SUD patients with co-occurring probable PTSD are more likely to use specific substances than adolescent SUD patients without PTSD, and how the use of these substances relates to PTSD symptoms. We found that adolescent SUD patients with probable PTSD start using substances at an earlier age, are more likely to use MDMA, and use it more frequently than adolescents with a SUD and a history of TEs but no PTSD, or adolescents with only a SUD. Additionally, we observed that in adolescent SUD patients with TE history, the use of MDMA is associated specifically with the presence of the avoidance SC. Finally, we report that adolescents with a history of TEs start using MDMA after the first occurrence of PTSD symptoms. The self-medication hypothesis posits that substance use and subsequent SUDs may be the result of an attempt to self-medicate co-occurring psychiatric disorders. This hypothesis postulates that the preference for a specific substance may be the result of their ability to reduce acute symptomatology. In terms of co-occurring PTSD, the self-medication hypothesis implies that a co-occurring SUD occurs because the substance of choice has specific PTSD-symptom-relieving effects. In fact, this pattern has been shown repeatedly in the context of alcohol use and PTSD, suggesting that after encountering TEs a common response is engaging in drinking to cope. In the context of the self-medication hypothesis, the increased use of MDMA in adolescents with cooccurring PTSD and SUD is not surprising. Since MDMA use in adolescents has been generally associated with a self-medication motive, and MDMA-assisted psychotherapy has recently been shown to reduce PTSD symptomatology, adolescents in our sample with PTSD and SUD may show increased use of MDMA because it decreases their distress induced by the different PTSD SCs. Our results indeed show, that a higher prevalence of MDMA use is specifically related to the presence of the avoidance SC. Symptoms of the avoidance cluster include 'feeling of detachment' or 'restricted range of affect' which might be associated with MDMA use since MDMA has been shown to induce heightened empathy, increased pro-social behaviourand is often used in social settings. On the other hand, side effects of MDMA such as increased body temperatureand increased blood pressuremight explain why MDMA use is not associated with hyperarousal, since the increased activation of the sympathetic nervous system might exacerbate negative aspects of hyperarousal. Furthermore, acute detrimental effects of MDMA on memorycould explain why the intrusion SC is not associated with its use: if memory is impaired, intrusive memories might also be suppressed. In light of the unique effects of MDMA it seems plausible that it is used by adolescents with a PTSD to reduce their avoidance-induced distress, and that this selfmedication use might continue unchecked and eventually develop into a SUD. This proposed association between MDMA use and avoidance symptoms might have clinical implications. As demonstrated by our results, a higher level of MDMA use might indicate the presence of other, untreated disorders such as PTSD. However, it is important to note that our results have little bearing on the discussion surrounding MDMA as an adjunct for PTSD therapy. Participants in our study received no psychotherapy and we have no way of assessing if their MDMA use has actually reduced PTSD symptomatology. This last point is especially important since the self-medication hypothesis is not entirely without fault.argues that the picture might be more complicated and that psychiatric symptoms not only contribute to substance use, but the reverse might also be possible: the use of psychoactive substances might lead to an increase in psychiatric symptomatology through the occurrence of withdrawal symptoms or adverse pharmacological effects. Indeed, another explanation for our observed results could be that frequent MDMA use has negative psychopathological consequences that worsen subclinical PTSD symptoms, leading to a fully developed PTSD. This conclusion is supported by evidence showing that MDMA users show increased psychopathology in the Symptom Checklist-90-R compared to poly-substance users without MDMA use. Additionally, MDMA use has been associated with psychiatric symptoms such as depression, prodromal psychotic symptomsor depersonalizationwhich often go hand in hand with PTSD. Moreover, regular MDMA use might impair memory, disturb sleepor diminish interest and excitementwhich could negatively influence the developmental process of PTSD. Finally, illicit MDMA use may further increase the risk of negative consequences, because of contamination with other psychoactive substances. For example, powder or pills sold as MDMA often contain synthetic cathinoneswith harsher side effects than MDMA. Nevertheless, we found that adolescents use MDMA on average two years after the first onset of PTSD symptoms, which is in line with research showing that adolescent MDMA use occurs later than mental health symptoms. This pattern of symptoms first -use later, can be considered further support for the self-medication hypothesis, suggesting that adolescent PTSD patients discover MDMA in their adolescence, and start using more frequently and subsequently develop a SUD in an effort to reduce their symptoms. Additionally, our findings of an earlier age of first substance use in patients with cooccurring SUD and PTSD might indicate an early exploration of self-medication options. Our results are unusual insofar as previous research has identified other substances to be associated with co-occurring PTSD and SUD and the avoidance SC. Specifically, adult alcohol use has been repeatedly associated with co-occurring PTSD and SUDand the presence of the avoidance cluster. However, this association is the result of comparing the level of symptoms between people who drink alcohol and people who do not. We, on the other hand, might not have found this association because our sample consisted of adolescents drinking alcohol at elevated levels already. Considering that 55% of our sample had used alcohol in the past month, which is a prevalence rate three times higher than in the general German adolescent population, our results might actually be in line with previous findings. Other studies used similar research designs asand concluded that levels of avoidance symptoms are higher in participants with regular use of opioids and benzodiazepines, as well as cocaine, cannabis, and alcoholcompared to users with lower or no use. Apart from the issue expanded upon above, these studies all consisted of adult samples. Since adolescents show different patterns of useand use substances in different settingsthan adults they might tend to use different substances for self-medication as well. Additionally, our study included participants who used various substances in the past month, and MDMA emerged as a factor nonetheless, indicating that the MDMA use might be more relevant for patients with PTSD and SUD than other substances used at the same time.
First, this study consists of cross-sectional, retrospective data, which means we cannot investigate how the use of psychoactive substances, especially MDMA, changes during the developmental course of a SUD or PTSD. Second, we based our calculations on pastmonth use of different substances, which represents only a snapshot of a participant's use history. Third, most of our measures, including our assessment of PTSD diagnosis, are based on self-report which might lead to social desirability or recall bias, which could lead to an underreporting of substance use and the true proportion of substance use in this population to be larger. Additionally, this procedure might overestimate the proportion of PTSD diagnoses in our sample. Future research would be well advised to include standardized instruments and more long-term measures of use, e.g. the use over the past year, or lifetime exposure. Fourth, in assessing the age of PTSD symptom onset and substance use we could only include few participants, limiting the validity of our results regarding this topic and leading to our study having a low power to detect potential effects. Fifth, our sample consisted of a specific and limited convenience sample only including adolescent, treatment-seeking SUD patients. Therefore, we are not able to make any conclusion about the role MDMA use might play in adolescents with only a PTSD diagnosis. Sixth, because of the need to use non-parametric testing it was not possible to control for sociodemographic confounders during our main analysis. Fortunately, gender differences between the groups were not mirrored in our substance use outcomes. Finally, we conducted a large number of tests increasing our likelihood of reporting false-positive results. As a countermeasure, we only considered results to be statistically significant if they survived a correction with the Bonferroni-Holm procedure.
This study showed that adolescent SUD patients with cooccurring probable PTSD are more likely to have used MDMA in the past month, and use it in higher frequency, than adolescents with only a SUD, regardless of additional TE. This finding might reflect an attempt to self-medicate, specifically to deal with the SC of avoidance. On the other hand, the greater MDMA use might have facilitated the development of more severe avoidance symptoms. Independent of directionality, these results should be taken into account by clinicians encountering this highly vulnerable patient group. Particular care should be taken to comprehensively assess if substances (like MDMA) are used as a form of self-medication. absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Stewart, L., Ferguson, B., Morgan, C. J. A. et al. · Journal of Psychopharmacology (2014)
Vizeli, P., Liechti, M. E. · Journal of Psychopharmacology (2017)
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