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Home/Research/5-MeO-DMT/Immunology & Inflammation

5-MeO-DMT for Immunology & Inflammation

5 papers and 0 clinical trials exploring 5-meo-dmt as a treatment for immunology & inflammation.

CompoundTryptamine

5-MeO-DMT

A potent tryptamine psychedelic known for profound mystical experiences, currently under clinical investigation for TRD and anxiety.

Full 5-MeO-DMT profile
IndicationOver 264 million people worldwide suffer from depression, with a significant subset experiencing related inflammatory conditions.

Immunology & Inflammation

Recent research highlights the potential of psychedelics, particularly psilocybin and MDMA, in modulating immune responses and inflammation, shedding light on their therapeutic implications for mood disorders and other immune-related conditions. Studies are beginning to uncover the mechanisms through which these compounds exert anti-inflammatory effects and promote neuroplasticity, particularly in the context of major depressive disorder (MDD).

Full Immunology & Inflammation profile

Academic Research

5 papers
Open Accessmeta

The potential of 5-methoxy-N,N-dimethyltryptamine in the treatment of alcohol use disorder: A first look at therapeutic mechanisms of action

This review (2024) examines the potential therapeutic mechanisms of action for alcoholism (AUD) treatment using 5-MeO-DMT. It highlights that 5-MeO-DMT can induce mystical experiences and ego-dissolution, leading to increased psychological flexibility and mindfulness, which may alleviate AUD symptoms. Additionally, preliminary evidence suggests that 5-MeO-DMT modulates neural oscillations and exhibits neuroplasticity and anti-inflammatory properties, indicating its potential clinical implications for AUD and related psychiatric comorbidities.

Published
April 10, 2024
Journal
Addiction Biology
Authors
Tap, S. C.
Open Accessmeta

The clinical pharmacology and potential therapeutic applications of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)

This review (2022) explores the current state of research surrounding 5-MeO-DMT. The authors provide food for thought on its therapeutic potential as well as the commercialization of the substance.

Published
February 11, 2022
Journal
Journal of Neurochemistry
Authors
Reckweg, J., Uthaug, M. V., Szabo, A., Davis, A. K., Lancelotta, R., Mason, N. L., Ramaekers, J. G.
Open Accessindividual

Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment

In a prospective study of 11 volunteers, inhalation of vaporised synthetic 5‑methoxy‑N,N‑dimethyltryptamine produced immediate increases in salivary cortisol and decreases in IL‑6, alongside improvements in affect and mindful non‑judgment that persisted to one week. These biomarker changes were not correlated with ratings of mental health or the psychedelic experience, suggesting a dissociation between subjective effects and acute neuroendocrine/immune responses.

Published
December 10, 2019
Journal
Psychopharmacology
Authors
Uthaug, M. V., Lancelotta, R., Szabo, A., Davis, A. K., Riba, J., Ramaekers, J. G.
Open Accessindividual

Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

Using shotgun mass spectrometry on human cerebral organoids treated with 5‑MeO‑DMT, the study identified 6,728 proteins of which 934 were differentially expressed, revealing anti‑inflammatory signatures and modulation of proteins linked to long‑term potentiation, dendritic spine formation and cytoskeletal/microtubule dynamics. This provides the first molecular insight into how 5‑MeO‑DMT alters human brain‑like tissue.

Published
October 9, 2017
Journal
Scientific Reports
Authors
Dakic, V., Nascimento, J. M., Sartore, R. C., de Moraes Maciel, R., de Araujo, D. B., Ribeiro, S., Martins-de-Souza, D., Rehen, S. K.
Paywallindividual

Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells

This in vitro (neuronal cell culture) study investigated the anti-inflammatory effects of NN-DMT and 5-MeO-DMT (100 μM), and demonstrate that its immunomodulatory effects on the functional activities of human dendritic cells operate through the sigma-1 receptor.

Published
August 29, 2014
Journal
PLOS ONE
Authors
Szabo, A., Kovacs, A., Frecska, E., Rajnavolgyi, E.

Clinical Trials

0 trials

No clinical trials have been tagged with both 5-MeO-DMT and Immunology & Inflammation yet.

Trials are continuously being added as new studies are registered.

Explore further

Search all 5-MeO-DMT papers Search all Immunology & Inflammation trials Full 5-MeO-DMT profile Full Immunology & Inflammation profile