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Home/Research/5-MeO-DMT/Peripartum

5-MeO-DMT for Peripartum

1 paper and 1 clinical trial exploring 5-meo-dmt as a treatment for peripartum.

CompoundTryptamine

5-MeO-DMT

A potent tryptamine psychedelic known for profound mystical experiences, currently under clinical investigation for TRD and anxiety.

Full 5-MeO-DMT profile
IndicationApproximately 15-20% of women experience postpartum depression worldwide.

Peripartum

Peripartum depression, including postpartum depression (PPD), is a significant mental health issue affecting new mothers, characterised by severe mood changes following childbirth. Current research into psychedelic treatments, particularly with compounds like esketamine and psilocybin, shows promising potential to alleviate depressive symptoms in this demographic.

Full Peripartum profile

Academic Research

1 paper
Paywallindividual

Inhaled Mebufotenin (GH001) for Adult Patients With Postpartum Depression: A Phase 2a Open-Label Clinical Trial

This Phase IIa open-label proof-of-concept trial (n=10) investigated GH001, an inhaled formulation of 5-MeO-DMT (up to 6, 12, and 18 mg), in women with postpartum depression. All patients responded and achieved remission by day 8, with effects first seen two hours after the final dose. It was well tolerated, with headache the most common mild to moderate side effect.

Published
June 3, 2026
Journal
Journal of Clinical Psychiatry
Authors
Johnson, M., Baldo, P. A., Arbe, E., Brennan, B., Cohen, S. E., Doolin, K., Gann, W., Gregory, D., Keady, S., Kriger, K., MacIsaac, R., Ratcliffe, S., Rubinow, D. R., Svendsen, C. B., Terwey, T. H., Tully, D., Valcheva, V., Zantvoord, J. B., Deligiannidis, K. M.

Clinical Trials

1 trial
TerminatedPhase II

Phase 2 Clinical Trial of GH001 in Postpartum Depression

This is a single-arm, open-label Phase II clinical trial (n=10) investigating the anti-depressive effects of GH001 in postpartum depression (PPD) patients.

Started
March 2, 2023
Type
interventional
Blinding
none
Randomized
No
Registry ID
NCT05804708

Explore further

Search all 5-MeO-DMT papers Search all Peripartum trials Full 5-MeO-DMT profile Full Peripartum profile