Ayahuasca for Bipolar Disorder

4 papers and 0 clinical trials exploring ayahuasca as a treatment for bipolar disorder.

Compoundclassic psychedelic

Ayahuasca

Ayahuasca is a botanical decoction combining DMT with MAO-inhibiting harmala alkaloids, producing intense psychedelic effects lasting 3-6 hours. Clinical trials show rapid, large antidepressant effects from a single dose, with a favourable safety profile in controlled settings.

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Indication45 million worldwide

Bipolar Disorder

Bipolar disorder, characterised by extreme fluctuations in mood, is a complex mental health condition that affects approximately 45 million people worldwide. Current research on psychedelics as a potential treatment is limited due to concerns about inducing manic episodes, but emerging evidence, particularly regarding ketamine, suggests promise for alleviating depressive symptoms associated with the disorder.

Full Bipolar Disorder profile

Academic Research

4 papers
Open Accessindividual

Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report

This case report describes the clinical profile of a man from Argentina with a family history of bipolar disorder who participated in a four-day Ayahuasca ceremony that led to the eruption of a hypomanic episode two days after, consisting of mystical and paranoid delusional ideas, auditory hallucinations, racing thoughts, disorganized behavior, elevated energy, and manic euphoria. Given that the remission of psychotic symptoms was immediately followed by an onset of depressive symptoms, the authors theorize that antidepressant effects of harmine may have occasioned the manic shift of his bipolar disorder.

Published
Journal
International Journal of Bipolar Disorders
Authors
Smith, J. M., Szmulewicz, A. G., Valerio, M. P.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ayahuasca and Bipolar Disorder yet.

Trials are continuously being added as new studies are registered.

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