Ayahuasca for Interpersonal Functioning & Social Connectedness

Enhancing mindfulness and compassion through an ayahuasca-inspired formulation containing N,N-DMT and harmine: A randomized controlled trial in healthy subjects

In a randomised, double‑blind, placebo‑controlled within‑subjects trial in 31 healthy volunteers, an ayahuasca‑inspired N,N‑DMT plus harmine formulation produced acute increases in mindfulness and both self‑ and other‑directed compassion one day after dosing compared with harmine or placebo, with larger effects in high‑sensitivity individuals. These findings suggest the formulation may have therapeutic potential similar to traditional ayahuasca and warrant further clinical investigation.

Published: June 19, 2025
Journal: Journal of Psychopharmacology
Authors: Aicher, H. D., Wicki, I. A., Meling, D., Mueller, M. J., Dornbierer, D. A., Scheidegger, M.

Open Accessindividual

Long-Term Mental Health and Wellbeing Outcomes Associated with Naturalistic Ayahuasca Consumption

This naturalistic longitudinal study (n=66) investigates the long-term effects of ayahuasca on mental health in adults with no prior exposure. Participants attending neo-shamanic ceremonies reported sustained improvements in depression, anxiety, stress, affect, personality traits, spirituality, and relationships up to 12 months. Individuals with depression or anxiety experienced lasting symptom reductions, while those without a diagnosis had short-term benefits. Alcohol and cannabis use decreased only at one month. Findings suggest ayahuasca's mental health benefits persist, with varying trajectories of change over time.

Published: February 20, 2025
Journal: Journal of Psychoactive Drugs
Authors: Pagni, B. A., Halman, A., Sarris, J., Chenhall, R., Bogenschutz, M. P., Perkins, D.

Open Accessmeta

Effects of classical psychedelics on implicit and explicit emotional empathy and cognitive empathy: a meta-analysis of MET task

This meta-analysis (s=5, n=158) of classic psychedelic effects on empathy using the Multifaceted Empathy Test (MET) finds significant enhancement of explicit and implicit emotional empathy, with no effect on cognitive empathy. The analysis covers studies up to November 2023 examining LSD, psilocybin, and ayahuasca.

Published: October 18, 2024
Journal: Scientific Reports
Authors: Olami, A., Peled-Avron, L.

Open Accessindividual

Meditating on psychedelics. A randomized placebo-controlled study of DMT and harmine in a mindfulness retreat

This double-blind, placebo-controlled study (n=40) investigates the effect of DMT-harmine ('pharmahuasca') on meditative states during a 3-day retreat with experienced meditators. It finds that participants who received DMT-harmine reported greater mystical-type experiences, non-dual awareness, and emotional breakthrough during acute effects, as well as greater psychological insight one day later, compared to the placebo group.

Published: September 27, 2024
Journal: Journal of Psychopharmacology
Authors: Meling, D., Egger, K., Aicher, H. D., Redondo, J. J., Mueller, J., Dornbierer, J., Temperli, E., Vasella, E. A., Caflisch, L., Pfeiffer, D. J., Schlomberg, J. T., Smallridge, J. W., Dornbierer, D. A., Scheidegger, M.

Paywallindividual

Effects of a Single Dose of Ayahuasca in College Students With Harmful Alcohol Use: A Single-blind, Feasibility, Proof-of-Concept Trial

In a single-blind proof-of-concept trial in 11 college students with harmful alcohol use, one dose of ayahuasca with psychological support was well tolerated and produced a short-term reduction in days drinking at 2–3 weeks that did not survive correction for multiple comparisons. The study demonstrates feasibility of the protocol and supports larger, controlled trials to assess efficacy.

Published: June 3, 2024
Journal: Journal of Clinical Psychopharmacology
Authors: Rodrigues, L. S., Rossi, G. N., Guerra, L. T. L., Maekawa, R. M., de Lima Osório, F., Bouso, J. C., Dos Santos, R. G., Santos, F. P., Paranhos, B. A. P. B., Yonamine, M., Hallak, J. E.

Open Accessindividual

Increases in Aesthetic Experience Following Ayahuasca Use: A Prospective, Naturalistic Study

In a prospective naturalistic study of 54 retreat attendees, participants showed increased aesthetic experience at one week and one month after an ayahuasca ceremony compared with baseline. These increases were not predicted by acute drug effects (mystical-type experiences, awe, ego dissolution), though the open‑label design limits causal conclusions.

Published: February 27, 2024
Journal: Journal of Humanistic Psychology
Authors: Aday, J. S., Bloesch, E. K., Davis, A. K., Domoff, S. E., Scherr, K., Woolley, J. D., Davoli, C. C., Aesthetic, A.

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Interpersonal Functioning & Social Connectedness

Academic Research

Enhancing mindfulness and compassion through an ayahuasca-inspired formulation containing N,N-DMT and harmine: A randomized controlled trial in healthy subjects

Long-Term Mental Health and Wellbeing Outcomes Associated with Naturalistic Ayahuasca Consumption

Effects of classical psychedelics on implicit and explicit emotional empathy and cognitive empathy: a meta-analysis of MET task

Meditating on psychedelics. A randomized placebo-controlled study of DMT and harmine in a mindfulness retreat

Effects of a Single Dose of Ayahuasca in College Students With Harmful Alcohol Use: A Single-blind, Feasibility, Proof-of-Concept Trial

Increases in Aesthetic Experience Following Ayahuasca Use: A Prospective, Naturalistic Study

Clinical Trials

Ayahuasca Assisted Psychotherapy for Grief

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