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Home/Research/Ibogaine/Neurological Injury

Ibogaine for Neurological Injury

6 papers and 2 clinical trials exploring ibogaine as a treatment for neurological injury.

CompoundIndole Alkaloid

Ibogaine

A unique indole alkaloid with complex pharmacology, investigated primarily for its capacity to interrupt substance use disorders and withdrawal.

Full Ibogaine profile
IndicationApproximately 15 million individuals experience a stroke annually, while traumatic brain injuries occur in around 69 million people worldwide each year.

Neurological Injury

Neurological injury encompasses various forms of brain damage resulting from trauma, strokes, or other factors, leading to significant functional impairment. Recent research into psychedelic compounds presents promising avenues for innovative therapeutic interventions aimed at enhancing recovery and alleviating associated psychological conditions such as PTSD and depression.

Full Neurological Injury profile

Academic Research

6 papers
Open Accessindividual

Clinical improvement following an integrative iboga microdosing protocol in post-concussive and hypoxic brain injury syndromes: a case series

This case series (n=3) describes three people with persistent symptoms after traumatic brain injury or hypoxic brain injury who took a 6-week iboga microdosing protocol alongside psychotherapy and supportive care. All three reported marked improvement, and two said their symptoms had fully resolved at long-term follow-up, but the authors do not claim the treatment caused these changes.

Published
June 3, 2026
Journal
Frontiers in Pharmacology
Authors
Tabaac, B. J., Carhart-Harris, R. L., Yung, T.
Open Accessindividual

Increased cortical thickness and decreased brain age among special operations veterans with blast TBI after a magnesium-ibogaine protocol

This secondary analysis of an observational study (n=30) - named MISTIC - of Special Operations Forces veterans with blast-related traumatic brain injury, examined ibogaine given with magnesium and found increased cortical thickness, larger subcortical volumes and a lower estimated brain age one month later. The authors note that the MRI changes could reflect neuroplastic effects, although the scans may also be influenced by non-structural factors.

Published
February 21, 2026
Journal
iScience
Authors
Geoly, A. D., Coetzee, J. P., Buchanan, D. M., Struckmann, W., Kim, B., Sridhar, M., Azeez, A., Lissemore, J. I., Cherian, K., Faerman, A., Keynan, J. N., Singal, P., Shanbour, A., Bandeira, I. D., Kratter, I. H., Adamson, M. M., Saggar, M., Rolle, C., Williams, N. R.
Paywallindividual

Mystical experiences during magnesium-Ibogaine are associated with improvements in PTSD symptoms in veterans

This secondary analysis of an open-label study (n=30) of male Veterans with traumatic brain injury found that greater intensity of mystical experiences during magnesium-ibogaine treatment was associated with larger reductions in PTSD severity both immediately and one month post-treatment, as well as greater reductions in peak alpha frequency at one month.

Published
February 1, 2026
Journal
Journal of Affective Disorders
Authors
Brown, R. E., Lissemore, J. I., Shinozuka, K. F., Coetzee, J. P., Faerman, A., Olash, C. A., Geoly, A. D., Buchanan, D. M., Cherian, K. N., Chaiken, A., Shamma, A., Sridhar, M., Hunegnaw, S. A., Johnson, N. D., Rolle, C. E., Adamson, M. M., Williams, N. R.
Paywallindividual

Magnesium-ibogaine therapy effects on cortical oscillations and neural complexity in veterans with traumatic brain injury

This analysis of an open-label observational study (n=30) found that magnesium-ibogaine therapy in combat veterans with traumatic brain injury (TBI) led to slower brain wave patterns and reduced neural complexity on EEG, which correlated with improvements in PTSD, anxiety, and cognitive function at one-month follow-up.

Published
July 24, 2025
Journal
Nature Mental Health
Authors
Lissemore, J. I., Chaiken, A., Keller, C. J., Williams, N. R., Cherian, K. N., Buchanan, D., Espil, F., Keynan, J. N., Sridhar, M., Rolle, C. E., Saggar, M.
Open Accessindividual

Magnesium-ibogaine therapy in veterans with traumatic brain injuries

This observational study (n=30) evaluates ibogaine (up to 980mg/70kg) in combination with magnesium (1-2 hours before and 12 hours later) in male Special Operations Forces veterans with predominantly mild traumatic brain injury (mTBI). The study assessed changes in disability, PTSD, depression, and anxiety immediately and one month after treatment using various scales. Results show significant improvements in functioning and psychological symptoms with no serious adverse events.

Published
January 5, 2024
Journal
Nature Medicine
Authors
Cherian, K. N., Keynan, J. N., Anker, L., Faerman, A., Brown, R. E., Shamma, A., Keynan, O., Coetzee, J. P., Batail, J. M., Phillips, A., Bassa, N. J., Sahlem, G. L., Inzunza, J., Millar, T., Dickinson, J., Rol, C. E., Keller, J., Adamson, M., Kratter, I. H., Williams, N. R.
Open Accessindividual

Prospective associations of psychedelic treatment for co-occurring alcohol misuse and posttraumatic stress symptoms among United States Special Operations Forces Veterans

This prospective study (n=86) evaluated the effects of ibogaine & 5-MeO-DMT treatment on risky alcohol use & PTSD symptoms among US Special Operations Forces Veterans. It found a significant reduction in alcohol use from pre-treatment to 1-month, 3-months, and 6-months post-treatment, and large differences between responders and non-responders in PTSD symptom and cognitive functioning change, suggesting that psychedelic-assisted therapy may hold promise for individuals with complex trauma and alcohol misuse.

Published
February 1, 2023
Journal
Military Medicine
Authors
Armstrong, S. B., Xin, Y., Sepeda, N. D., Polanco, M., Averill, L. A., Davis, A. K.

Clinical Trials

2 trials
WithdrawnPhase II

Trifecta Research Study

Non-randomised, parallel interventional study (n=40) testing sequences of HRT, MeRT, ibogaine and 5‑MeO‑DMT in Special Operations Forces veterans with PTSD and cognitive difficulties following TBI.

Started
March 1, 2025
Type
interventional
Blinding
none
Randomized
No
Registry ID
NCT06810765
CompletedPhase NA

Pre-post Evaluation of the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans With Repeated Blast Exposure

This observational cohort study (n=30) evaluated the safety and efficacy of Ibogaine-Magnesium Therapy in veterans with sequelae of repeated blast exposure.

Started
November 15, 2021
Type
observational
Blinding
none
Randomized
No
Registry ID
NCT04313712

Explore further

Search all Ibogaine papers Search all Neurological Injury trials Full Ibogaine profile Full Neurological Injury profile