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Home/Research/Ketamine/Public Health, Prevention & Behaviour Change

Ketamine for Public Health, Prevention & Behaviour Change

26 papers and 0 clinical trials exploring ketamine as a treatment for public health, prevention & behaviour change.

CompoundArylcyclohexylamine

Ketamine

A dissociative anesthetic with rapid-acting antidepressant properties, widely used in clinical settings for mood and pain disorders.

Full Ketamine profile
IndicationApproximately 20% of adults experience a mental health issue in any given year worldwide.

Public Health, Prevention & Behaviour Change

Current research into psychedelics as a means of public health intervention highlights their potential in addressing various behavioural health conditions. As clinical trials expand, the implications for prevention and behaviour change are becoming increasingly apparent.

Full Public Health, Prevention & Behaviour Change profile

Academic Research

26 papers
Open Accessindividual

Efficacy of esketamine nasal spray over quetiapine extended release over the short and long term: sensitivity analyses of ESCAPE-TRD, a randomised phase IIIb clinical trial

Sensitivity analyses of the randomised ESCAPE‑TRD trial confirmed that adjunctive esketamine nasal spray was consistently superior to quetiapine extended release for achieving remission at Week 8 and remaining relapse‑free to Week 32 (relative risks 1.46–1.84, all p<0.05). Esketamine also shortened time to first and confirmed remission (hazard ratios ≈1.66–1.71), supporting the robustness of the original findings.

Published
December 2, 2024
Journal
British Journal of Psychiatry
Authors
Young, A. H., Llorca, P. M., Fagiolini, A., Falkai, P., Cardoner, N., Nielsen, R. E., Blomqvist, O., Godinov, Y., Rive, B., Diels, J., Mulhern-Haughey, S., Reif, A.
Open Accessindividual

Randomized Placebo-Controlled Phase 2 Study of Extended-Release Ketamine Tablets (R-107) for Treatment-Resistant Depression - the BEDROC Study

In this phase 2 randomised, placebo‑controlled enrichment study, extended‑release oral ketamine tablets (R‑107) given twice weekly maintained antidepressant response in treatment‑resistant depression, with the 180 mg dose producing a significant 13‑week MADRS improvement versus placebo (least‑square mean difference −6.1, P = 0.019). R‑107 was generally well tolerated with minimal blood‑pressure, sedation or dissociation effects, showed a dose–response reduction in relapse rates, and most dosing was performed at home.

Published
June 24, 2024
Journal
Nature Medicine
Authors
Glue, P., Loo, C., Fam, J., Lane, H. Y., Young, A., Surnam, P.
Open Accessindividual

Esketamine combined with a mindfulness-based intervention for individuals with alcohol problems

In a double-blind, randomised pilot study of 28 people with alcohol problems, sublingual esketamine (115.1 mg) combined with two weeks of daily mindfulness-based intervention increased psychological engagement with the practice and produced transient reductions in alcohol craving versus placebo. Esketamine also elicited greater mystical and dissociative experiences, suggesting these altered states may underlie enhanced engagement and potential therapeutic benefit.

Published
June 11, 2024
Journal
Journal of Psychopharmacology
Authors
Gent, E. M., Bryan, J. W., Cleary, M. A., Clarke, T. I., Holmwood, H. D., Nassereddine, R. O., Salway, C., Depla, S., Statton, S., Krecké, J., Morgan, C. J.
Paywallindividual

Anti-suicidal effects of IV ketamine in a real-world setting

This community-based study (n=295) examined the impact of intravenous ketamine treatment on suicidality. Using growth mixture modelling, three trajectory groups were identified: one with moderate baseline scores showing gradual improvement (n=170, 57.6%), another with severe baseline scores showing no improvement (n=63, 21%), and a third with rapid improvement (n=62, 21%). Among clinical and demographic variables, only higher scores on active thoughts of death and/or plan predicted a lack of benefit from treatment for those with severe baseline CHRT-SR scores. The findings support ketamine's potential effectiveness in addressing suicidality in a proportion of patients.

Published
January 1, 2024
Journal
Psychiatry Research
Authors
O'Brien, B., Lee, J., Kim, S., Nandra, G. S., Pannu, P., Tamman, A. J. F., Amarneh, D., Swann, A. C., Murphy, N., Averill, L. A., Jha, M. K., Mathew, S. J.
Paywallindividual

Esketamine Nasal Spray versus Quetiapine for Treatment-Resistant Depression

This open-label Phase IIIb trial (n=676) compared the efficacy of esketamine nasal spray and extended-release quetiapine, combined with an SSRI or SNRI, in patients with treatment-resistant depression (TRD). The study found that a significantly higher percentage of patients in the esketamine group achieved remission at week 8 (27.1% vs 17.6%) and had no relapse through week 32 after remission at week 8 (21.7% vs 14.1%). Adverse events were consistent with the established safety profiles of the trial treatments.

Published
October 5, 2023
Journal
New England Journal of Medicine
Authors
Reif, A., Bitter, I., Buyze, J., Cebulla, K., Frey, R., Ito, T., Kambarov, Y., Llorca, P-M., Oliveira-Maia, A. J., Messer, T., Mulhern-Haughey, S., Fu, D. J.
Paywallindividual

Access and real-world use patterns of esketamine nasal spray among patients with treatment-resistant depression covered by private or public insurance

This retrospective analysis (n=535) describes the access and real-world use patterns of esketamine nasal spray among adults with treatment-resistant depression (TRD). Of the pharmacy claims for esketamine, 34.6% were approved, 46.3% were rejected, and 19.1% were abandoned. The approval rate increased to 85.2% by the second treatment session. Among 273 patients who initiated esketamine (mean age 49.3 years; 66.3% female), the mean number of sessions was 11.8 over a mean of 11.8 months, with 47.6% completing at least 8 sessions, and 93.8% of those completing induction continuing treatment.

Published
August 3, 2023
Journal
Current Medical Research and Opinion
Authors
Teeple, A., Zhdanava, M., Pilon, D., Caron-Lapointe, G., Lefebvre, P., Joshi, K.

Clinical Trials

0 trials

No clinical trials have been tagged with both Ketamine and Public Health, Prevention & Behaviour Change yet.

Trials are continuously being added as new studies are registered.

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Search all Ketamine papers Search all Public Health, Prevention & Behaviour Change trials Full Ketamine profile Full Public Health, Prevention & Behaviour Change profile