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Home/Research/LSD/Tobacco/Nicotine Use Disorder (TUD)

LSD for Tobacco/Nicotine Use Disorder (TUD)

10 papers and 0 clinical trials exploring lsd as a treatment for tobacco/nicotine use disorder (tud).

Compoundclassic psychedelic

LSD

LSD is a classic psychedelic ergoline with high potency at microgram doses and an 8-12 hour duration of action, mediated primarily via 5-HT2A receptor agonism. Modern Phase IIb data in generalised anxiety disorder and FDA Breakthrough Therapy Designation for MM120 have reignited clinical development.

Full LSD profile
Indication1.3 billion smokers worldwide.

Tobacco/Nicotine Use Disorder (TUD)

Tobacco Use Disorder (TUD) presents significant challenges for public health, and emerging research indicates that psychedelic compounds may offer novel therapeutic avenues for treatment. Initial studies highlight the potential of psychedelics like ayahuasca and ibogaine in reducing tobacco dependence.

Full Tobacco/Nicotine Use Disorder (TUD) profile

Academic Research

10 papers
Open Accessindividual

Health-related behavioral changes following the use of psychedelics in naturalistic settings

This cross-sectional study (n=2,510) of US adults with psychedelic experience found that participants retrospectively reported widespread improvements in health behaviours including reduced alcohol (66%) and tobacco (49%) use, better dietary habits (49%), and decreased impulsivity (48-72%), with microdosers and frequent users showing greater positive changes.

Published
August 1, 2025
Journal
Preventative Medicine Reports
Authors
Teixeira, P. J., Jain, R., Penn, A. D., Cole, S. P., Jain, S., Moller, A. C., Amaro, H., Raison, C.
Open Accessindividual

The association between naturalistic use of psychedelics and co-occurring substance use disorders

Using 2017 NSDUH data (n=56,276), the authors found past naturalistic use of peyote/mescaline was associated with lower odds of past-year substance dependence or abuse (adjusted OR 0.68, p<0.001), whereas past LSD and psilocybin use were associated with increased odds; none of the classic psychedelics were linked to nicotine dependence. The paper notes it is unclear whether these differences reflect pharmacological properties or the cultural/ceremonial contexts of peyote/mescaline use.

Published
January 10, 2023
Journal
Frontiers in Psychiatry
Authors
Rabinowitz, J., Lev-Ran, S., Gross, R.
Open Accessindividual

Associations between classic psychedelics and nicotine dependence in a nationally representative sample

In a nationally representative sample of 214,505 US adults, lifetime use of psilocybin, peyote and mescaline was associated with modestly lower odds of current nicotine dependence, whereas lifetime LSD use was associated with higher odds; experimental studies are needed to establish causality and assess therapeutic potential for smoking cessation.

Published
June 22, 2022
Journal
Scientific Reports
Authors
Jones, G. M., Lipson, J., Nock, M. K.
Paywallmeta

Human behavioral pharmacology of psychedelics

This commentary (2021) provides an overview of the human behavioural pharmacology of the classic psychedelic; psilocybin, LSD and DMT. Special considerations when conducting human research with psychedelics are discussed as well as the subjective, physiological, and clinical effects of these substances.

Published
January 1, 2022
Journal
Advances in Pharmacology
Authors
Strickland, J. C., Johnson, M. W.
Open Accessindividual

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1

This mice study finds that, using mice with specific receptor deficiencies, the signals are β-arrestin-2 (βArr; type of protein important in signalling) mediated, but not βarr1 mediated. This line of evidence points towards the requirement of βArr2 for LSD's psychedelic effects.

Published
September 3, 2021
Journal
Scientific Reports
Authors
Rodriguiz, R. M., Nadkarni, V., Means, C. R., Pogorelov, V. M., Chiu, Y. T., Roth, B. L., Wetsel, W. C.
Paywallindividual

Association Between Lifetime Classic Psychedelic Use and Hypertension in the Past Year

Using nationally representative US survey data (NSDUH 2005–2014), lifetime use of classic psychedelics was associated with lower odds of past‑year hypertension after adjustment (adjusted odds ratio 0.86, 95% CI 0.81–0.91), an effect driven specifically by lifetime tryptamine use (aOR 0.80, 95% CI 0.73–0.89). These cross‑sectional findings suggest a potential protective link but cannot establish causality; randomised controlled trials are needed to probe mechanisms and causal effects on blood pressure.

Published
May 1, 2021
Journal
Hypertension
Authors
Simonsson, O., Hendricks, P. S., Carhart-Harris, R., Kettner, H., Osika, W.

Clinical Trials

0 trials

No clinical trials have been tagged with both LSD and Tobacco/Nicotine Use Disorder (TUD) yet.

Trials are continuously being added as new studies are registered.

Explore further

Search all LSD papers Search all Tobacco/Nicotine Use Disorder (TUD) trials Full LSD profile Full Tobacco/Nicotine Use Disorder (TUD) profile