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Home/Research/MDMA/Borderline Personality Disorder (BPD)

MDMA for Borderline Personality Disorder (BPD)

1 paper and 2 clinical trials exploring mdma as a treatment for borderline personality disorder (bpd).

Compoundempathogen

MDMA

MDMA is a synthetic empathogen that enhances monoamine release, producing prosocial and anxiolytic effects without frank hallucinosis. Two Phase III trials demonstrated significant PTSD symptom reductions, though FDA review raised concerns about blinding, durability, and safety characterisation.

Full MDMA profile
Indication1.8% of adults globally.

Borderline Personality Disorder (BPD)

Research into psychedelic-assisted therapies for Borderline Personality Disorder (BPD) indicates promising potential, particularly with compounds such as ketamine and MDMA, which may enhance emotional processing and neuroplasticity. However, systematic exclusion of BPD patients from psychedelic trials has limited available data, highlighting the need for dedicated research in this area.

Full Borderline Personality Disorder (BPD) profile

Academic Research

1 paper
Paywallmeta

MDMA-Assisted Psychotherapy for Borderline Personality Disorder

This review (2022) makes the cases for using MDMA-assisted therapy (MDMA-AT) in the treatment of borderline personality disorder (BPD). The authors draw parallels between using MDMA-AT to treat disorders similar to BPD, such as PTSD, and provide considerations for designing future clinical trials.

Published
October 25, 2022
Journal
Focus
Authors
Traynor, J. M., Roberts, D. E., Ross, S., Zeifman, R., Choi-Kain, L.

Clinical Trials

2 trials
RecruitingPhase II

MDMA in Borderline Personality Disorder (MDMA in BPD)

This open-label trial (n=10) will investigate the effects of a single dose of MDMA on social cognition in adults with Borderline Personality Disorder (BPD).

Started
February 1, 2025
Type
interventional
Blinding
none
Randomized
No
Registry ID
NCT06683014
Not yet recruitingPhase II

Pilot investigation of psychedelic-assisted psychotherapy for treatment of post-traumatic stress disorder (PTSD) in people diagnosed with co-occurring borderline personality disorder – a controlled before-and-after study

This interventional controlled study (n=20) will evaluate GPM-Complex psychotherapy with or without 2–5 MDMA-assisted sessions (initial 80 mg with optional 40 mg supplemental dose) for treating PTSD in individuals with co-occurring BPD.

Started
July 26, 2024
Type
interventional
Blinding
none
Randomized
No
Registry ID
ACTRN12624000871549

Explore further

Search all MDMA papers Search all Borderline Personality Disorder (BPD) trials Full MDMA profile Full Borderline Personality Disorder (BPD) profile