Mescaline for Anxiety Disorders

7 papers and 0 clinical trials exploring mescaline as a treatment for anxiety disorders.

CompoundPhenethylamine

Mescaline

A naturally occurring phenethylamine psychedelic found in certain cacti, investigated for its role in religious practice and psychiatric research.

Full Mescaline profile

Indication300 million worldwide

Anxiety Disorders

Anxiety disorders, affecting around 300 million people globally, are among the most prevalent mental health conditions. Emerging clinical research suggests that various psychedelics, including psilocybin, MDMA, and LSD, hold potential for alleviating anxiety symptoms through innovative therapeutic approaches.

Full Anxiety Disorders profile

Academic Research

7 papers

Open Accessindividual

Naturalistic psychedelic use and changes in depressive symptoms

This longitudinal observational study (n=12,345) of U.S. residents found that naturalistic psychedelic use (n=505, 4.1% of participants) was associated with modest increases in depressive symptoms, particularly when occurring in 'risk contexts' characterised by negative mindset and lack of psychological support, with challenging psychedelic experiences mediating this relationship and suggesting that unsupervised psychedelic use may not be generally therapeutic and could worsen depression under certain circumstances.

Published: December 1, 2025
Journal: Journal of Affective Disorders
Authors: Goldberg, S. B., Hendricks, P. S., Osika, W., Simonsson, O., Swords, C. M.

Open Accessindividual

Safety pharmacology of acute mescaline administration in healthy participants

Pooled analysis of two double‑blind, randomized, placebo‑controlled studies (48 participants, 96 administrations) found that single oral doses of mescaline 100–800 mg produced dose‑dependent increases in positive subjective effects with only moderate autonomic changes and no clinically significant liver, kidney or haematological abnormalities. Although nausea was dose‑limiting and small proportions experienced transient diastolic hypertension, tachycardia, fever or “flashbacks”, single doses up to 800 mg were considered safe with respect to acute psychological and physical harm in healthy participants in a controlled clinical setting.

Published: November 25, 2024
Journal: British Journal of Clinical Pharmacology
Authors: Humbert-Droz, M.

Open Accessindividual

The epidemiology of mescaline use: Pattern of use, motivations for consumption, and perceived consequences, benefits, and acute and enduring subjective effects

A web-based survey of 452 English-speaking adults found mescaline was typically used infrequently for spiritual or nature-related reasons and produced moderate mystical-type acute effects with minimal challenging effects and few reported legal, psychological or medical harms. About half of respondents had a psychiatric condition and most (>67%) reported improvements after their most memorable mescaline experience, with no differences in effect intensity across mescaline sources, suggesting low abuse potential.

Published: May 5, 2021
Journal: Journal of Psychopharmacology
Authors: Davis, A. K., Davis, D., Dolan, S. B., Haas, T. F., Ramaekers, J. G., Timmermann, C., Uthaug, M. V.

Open Accessindividual

Naturalistic Use of Mescaline Is Associated with Self-Reported Psychiatric Improvements and Enduring Positive Life Changes

This survey study (n=452) found that the use of mescaline led to improvements in scores on clinical conditions for those suffering from clinical conditions (anxiety 80%, depression 86%, PTSD & AUD 76%). Those who scored higher on acute mystical experience (MEQ30), ego dissolution, and psychological insight had larger improvement than those who scored lower.

Published: March 23, 2021
Journal: ACS Pharmacology and Translational Science
Authors: Agin-Liebes, G. I., Davis, A. K., Lancelotta, R., Ramaekers, J. G., Uthaug, M. V.

Open Accessindividual

Long-lasting subjective effects of LSD in normal subjects

This double-blind cross-over trial (n=16) found that LSD (200μg) led to positive well-being/life-satisfaction scores up to 12 months later. The subjects experienced it as one of the top 10 most meaningful experiences (70%) in their lives.

Published: September 16, 2017
Journal: Psychopharmacology
Authors: Liechti, M. E., Schmid, Y.

Open Accessindividual

Psychedelics not linked to mental health problems or suicidal behavior: A population study.

In a nationally representative sample of 135,095 US adults (19,299 lifetime psychedelic users), lifetime use of LSD, psilocybin or mescaline was not associated with increased odds of past‑year serious psychological distress, mental‑health treatment, suicidal thoughts/plans/attempts, depression or anxiety after adjusting for sociodemographics, other drug use and childhood depression. The authors conclude psychedelics are unlikely to be independent risk factors for mental health problems and question the public‑health rationale for their prohibition.

Published: March 5, 2015
Journal: Journal of Psychopharmacology
Authors: Johansen, P. Ø., Krebs, T. S.

Clinical Trials

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No clinical trials have been tagged with both Mescaline and Anxiety Disorders yet.

Trials are continuously being added as new studies are registered.

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Mescaline for Anxiety Disorders

Mescaline

Anxiety Disorders

Academic Research

Naturalistic psychedelic use and changes in depressive symptoms

Safety pharmacology of acute mescaline administration in healthy participants

The epidemiology of mescaline use: Pattern of use, motivations for consumption, and perceived consequences, benefits, and acute and enduring subjective effects

Naturalistic Use of Mescaline Is Associated with Self-Reported Psychiatric Improvements and Enduring Positive Life Changes

Long-lasting subjective effects of LSD in normal subjects

Psychedelics not linked to mental health problems or suicidal behavior: A population study.

Clinical Trials

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