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Home/Research/Mescaline/Creativity

Mescaline for Creativity

3 papers and 0 clinical trials exploring mescaline as a treatment for creativity.

CompoundPhenethylamine

Mescaline

A naturally occurring phenethylamine psychedelic found in certain cacti, investigated for its role in religious practice and psychiatric research.

Full Mescaline profile
Indication300 million adults struggling with creative blocks globally.

Creativity

Psychedelics have emerged as potential enhancers of creativity, influencing both divergent and convergent thinking processes. Current research indicates their capacity to disrupt cognitive rigidity and promote innovative thought patterns, warranting further exploration into their therapeutic and recreational applications.

Full Creativity profile

Academic Research

3 papers
Paywallmeta

The risk of chronic psychedelic and MDMA microdosing for valvular heart disease

This review (2023) covers in vitro, animal, and clinical studies to assess the potential risk of valvular heart disease (VHD) from microdosing psychedelic substances, focusing on LSD, psilocybin, mescaline, DMT, and MDMA due to their interaction with the serotonin 5-HT2B receptor. Findings show that all these compounds, except mescaline (due to low potency), were partial agonists at the 5-HT2B receptor. While safety margins from typical microdoses were greater than known valvulopathogens, there remains a potential risk. No studies directly evaluated VHD risk for the four psychedelics, but some evidence suggests chronic ingestion of full doses of MDMA might be linked to VHD.

Published
August 12, 2023
Journal
Journal of Psychopharmacology
Authors
Tagen, M., Mantuani, D., Van Heerden, L., Holstein, A., Klumpers, L. E., Knowles, R.
Open Accessmeta

Psychedelics and Creativity: a Review of the Quantitative Literature

This review (2015, pre-print) of the psychedelics literature on creativity argues that creativity is too elusive/inconsistent a measure that is confounded by other changes.

Published
June 30, 2015
Journal
Preprints
Authors
Baggot, M. J.
Paywallindividual

Psychedelic Agents in Creative Problem-Solving: A Pilot Study

This pilot study of 27 professionally employed men found that a single, carefully structured psychedelic session with LSD-25 or mescaline appeared to facilitate creative problem‑solving, especially during the “illumination” phase. Subjective reports, creativity tests and assessments of solution utility suggested that enhanced creative ability persisted for some participants for several weeks afterwards.

Published
August 1, 1966
Journal
Psychological Reports
Authors
Harman, W. W., McKim, R. H., Mogar, R. E., Fadiman, J., Stolaroff, M. J.

Clinical Trials

0 trials

No clinical trials have been tagged with both Mescaline and Creativity yet.

Trials are continuously being added as new studies are registered.

Explore further

Search all Mescaline papers Search all Creativity trials Full Mescaline profile Full Creativity profile