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Home/Research/Salvia Divinorum/Chronic Pain

Salvia Divinorum for Chronic Pain

7 papers and 0 clinical trials exploring salvia divinorum as a treatment for chronic pain.

CompoundDiterpenoid

Salvia Divinorum

A specialized plant species that produces salvinorin A, a potent and selective kappa-opioid agonist with intense, short-lived effects.

Full Salvia Divinorum profile
IndicationOver 1.5 billion worldwide.

Chronic Pain

Chronic pain is increasingly recognised as a multifaceted condition that may respond to psychedelic therapies, which are gaining attention in clinical settings for their potential efficacy in pain management. Recent research indicates that compounds such as psilocybin and MDMA are entering clinical trials aimed at exploring their therapeutic effects on chronic pain syndromes.

Full Chronic Pain profile

Academic Research

7 papers
Paywallindividual

Acute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A

This fMRI study explores the effects of psilocybin (a serotonergic psychedelic) and Salvinorin-A (a kappa-opioid receptor agonist) on resting-state functional connectivity (FC) in nonhuman primates. It reveals both drugs influence FC around the thalamus, claustrum, prefrontal cortex (PFC), and default mode network (DMN), with similarities and differences noted between them.

Published
June 25, 2024
Journal
ACS Chemical Neuroscience
Authors
Bagdasarian, F. A., Hansen, H. D., Chen, J., Yoo, C. H., Placzek, M. S., Hooker, J. M., Wey, H. Y.
Paywallindividual

The kappa opioid receptor and the sleep of reason: Cortico-subcortical imbalance following salvinorin-A

Acute administration of salvinorin-A, a highly selective kappa opioid receptor agonist, produced dramatic dissociative psychotomimetic effects without dysphoria and revealed a cortico–subcortical imbalance. Neurophysiologically this was reflected by widespread cortical hypoperfusion and reduced cortical EEG alpha (with increased delta and gamma) alongside increased blood flow in medial temporal regions (amygdala, hippocampal gyrus) and the cerebellum.

Published
September 19, 2021
Journal
International Journal of Neuropsychopharmacology
Authors
Ona, G., Sampedro, F., Romero, S., Valle, M., Camacho, V., Migliorelli, C., Mañanas, M. Á., Antonijoan, R. M., Puntes, M., Coimbra, J., Ballester, M. R., Garrido H Msc, M., Riba, J.
Open Accessmeta

Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action

This review (2019) examines the analgesic, anti-inflammatory, and psychoactive properties of the hallucinogenic plant Salvia Divinorum and its bioactive (analog) constituents.

Published
March 22, 2019
Journal
Journal of Pain Research
Authors
Coffeen, U., Pellicer, F.
Paywallmeta

The Use of Salvia divinorum from a Mazatec Perspective

This book chapter (2018) investigates the use of salvia divinorum by the Mazatec people. Applications discussed include headaches (pain), inflammation, addiction, and depression. Next to medicinal and psychotherapeutic applications, the inner exploration (recreational) purposes are also discussed.

Published
April 29, 2018
Journal
Plant Medicines Healing and Psychedelic Science
Authors
Maqueda, A. E.
Open Accessmeta

A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics

This review (2016) examines the psychoactive properties and therapeutic potential of Salvinorin A, a kappa-opioid receptor agonist that is the bioactive constituent of the indigenous plant Salvia divinorum. Next to highly potent psychoactive properties as a dissociative hallucinogen, preliminary scientific evidence also indicates it may have broad-range therapeutic applications for treating addiction, inflammation, pain, and depression.

Published
May 1, 2017
Journal
Phytochemistry
Authors
Cruz, A. P. M., Domingos, S., Gallardo, E., Martinho, A.
Paywallindividual

Synthesis and κ-opioid receptor activity of furan-substituted salvinorin A analogues

This animal study (n=12) synthesized several different furan-substituted salvinorin A analogs and identified three potent variants which reduced drug-induced reinstatement of cocaine-seeking behavior, without producing the sedation observed with other κ-opioid agonists.

Published
December 9, 2014
Journal
Journal of Medicinal Chemistry
Authors
Riley, A. P., Groer, C. E., Young, D., Ewald, A. W., Kivell, B. M., Prisinzano, T. E.

Clinical Trials

0 trials

No clinical trials have been tagged with both Salvia Divinorum and Chronic Pain yet.

Trials are continuously being added as new studies are registered.

Explore further

Search all Salvia Divinorum papers Search all Chronic Pain trials Full Salvia Divinorum profile Full Chronic Pain profile