Salvia Divinorum for Depressive Disorders

8 papers and 0 clinical trials exploring salvia divinorum as a treatment for depressive disorders.

CompoundDiterpenoid

Salvia Divinorum

A specialized plant species that produces salvinorin A, a potent and selective kappa-opioid agonist with intense, short-lived effects.

Full Salvia Divinorum profile

IndicationApproximately 260 million people worldwide are affected by depression.

Depressive Disorders

Depressive disorders, particularly major depressive disorder (MDD), are significant contributors to global mental health issues. Research into the therapeutic potential of psychedelics, such as psilocybin and ketamine, offers promising avenues for treatment, especially for cases that are resistant to conventional therapies.

Full Depressive Disorders profile

Academic Research

8 papers

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Acute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A

This fMRI study explores the effects of psilocybin (a serotonergic psychedelic) and Salvinorin-A (a kappa-opioid receptor agonist) on resting-state functional connectivity (FC) in nonhuman primates. It reveals both drugs influence FC around the thalamus, claustrum, prefrontal cortex (PFC), and default mode network (DMN), with similarities and differences noted between them.

Published: June 25, 2024
Journal: ACS Chemical Neuroscience
Authors: Bagdasarian, F. A., Hansen, H. D., Chen, J., Yoo, C. H., Placzek, M. S., Hooker, J. M., Wey, H. Y.

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The kappa opioid receptor and the sleep of reason: Cortico-subcortical imbalance following salvinorin-A

Acute administration of salvinorin-A, a highly selective kappa opioid receptor agonist, produced dramatic dissociative psychotomimetic effects without dysphoria and revealed a cortico–subcortical imbalance. Neurophysiologically this was reflected by widespread cortical hypoperfusion and reduced cortical EEG alpha (with increased delta and gamma) alongside increased blood flow in medial temporal regions (amygdala, hippocampal gyrus) and the cerebellum.

Published: September 19, 2021
Journal: International Journal of Neuropsychopharmacology
Authors: Ona, G., Sampedro, F., Romero, S., Valle, M., Camacho, V., Migliorelli, C., Mañanas, M. Á., Antonijoan, R. M., Puntes, M., Coimbra, J., Ballester, M. R., Garrido H Msc, M., Riba, J.

Open Accessindividual

Neurochemical models of near-death experiences: A large-scale study based on the semantic similarity of written reports

This large-scale data-analytic study compared the semantic similarity of psychoactive trip reports (n≈15,000) and narrative accounts Near-Death Experiences (n=625), and found that ketamine (followed by salvinorin A and DMT) bared the most resemblance to the experience of 'dying'. The authors speculate that a ketamine model of Near-Death Experiences may indicate a neuroprotective function of endogenous NMDA antagonists released in the proximity of death.

Published: March 1, 2019
Journal: Consciousness and Cognition
Authors: Martial, C., Cassol, H., Charland-Verville, V, Erowid, E., Pallavicini, C., Sanz, C., Vivo, R. M, Zamberlan, F., Erowid, F., Laureys, S., Greyson, B., Tagliazucchi, E.

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The Use of Salvia divinorum from a Mazatec Perspective

This book chapter (2018) investigates the use of salvia divinorum by the Mazatec people. Applications discussed include headaches (pain), inflammation, addiction, and depression. Next to medicinal and psychotherapeutic applications, the inner exploration (recreational) purposes are also discussed.

Published: April 29, 2018
Journal: Plant Medicines Healing and Psychedelic Science
Authors: Maqueda, A. E.

Open Accessmeta

A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics

This review (2016) examines the psychoactive properties and therapeutic potential of Salvinorin A, a kappa-opioid receptor agonist that is the bioactive constituent of the indigenous plant Salvia divinorum. Next to highly potent psychoactive properties as a dissociative hallucinogen, preliminary scientific evidence also indicates it may have broad-range therapeutic applications for treating addiction, inflammation, pain, and depression.

Published: May 1, 2017
Journal: Phytochemistry
Authors: Cruz, A. P. M., Domingos, S., Gallardo, E., Martinho, A.

Open Accessmeta

A systematic review of the effects of novel psychoactive substances ‘legal highs’ on people with severe mental illness

This systematic review (mostly case reports) found scarce but consistent evidence that novel psychoactive substances can precipitate new or worsening psychotic symptoms, marked behavioural disturbance (agitation, aggression) and physiological changes in people with severe mental illness. Findings are limited by the reliance on case studies, and the authors call for clinicians to ask directly about NPS use and for further research into long‑term mental and physical effects.

Published: April 1, 2016
Journal: Journal of Psychiatric and Mental Health Nursing
Authors: Gray, R., Bressington, D., Hughes, E., Ivanecka, A.

Clinical Trials

0 trials

No clinical trials have been tagged with both Salvia Divinorum and Depressive Disorders yet.

Trials are continuously being added as new studies are registered.

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Salvia Divinorum for Depressive Disorders