Salvia Divinorum for Healthy Volunteers

5 papers and 0 clinical trials exploring salvia divinorum as a treatment for healthy volunteers.

CompoundDiterpenoid

Salvia Divinorum

A specialized plant species that produces salvinorin A, a potent and selective kappa-opioid agonist with intense, short-lived effects.

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IndicationApproximately 300 million people affected by depression worldwide.

Healthy Volunteers

Research involving healthy volunteers has expanded to investigate the therapeutic potentials of various psychedelics for mental health conditions. Recent findings, emphasizing compounds like psilocybin and DMT, illustrate a promising future for psychedelic-assisted therapies.

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Academic Research

5 papers

Paywallindividual

The kappa opioid receptor and the sleep of reason: Cortico-subcortical imbalance following salvinorin-A

Acute administration of salvinorin-A, a highly selective kappa opioid receptor agonist, produced dramatic dissociative psychotomimetic effects without dysphoria and revealed a cortico–subcortical imbalance. Neurophysiologically this was reflected by widespread cortical hypoperfusion and reduced cortical EEG alpha (with increased delta and gamma) alongside increased blood flow in medial temporal regions (amygdala, hippocampal gyrus) and the cerebellum.

Published: September 19, 2021
Journal: International Journal of Neuropsychopharmacology
Authors: Ona, G., Sampedro, F., Romero, S., Valle, M., Camacho, V., Migliorelli, C., Mañanas, M. Á., Antonijoan, R. M., Puntes, M., Coimbra, J., Ballester, M. R., Garrido H Msc, M., Riba, J.

Open Accessindividual

Time course of pharmacokinetic and hormonal effects of inhaled high-dose salvinorin A in humans

High‑dose inhaled salvinorin A produced peak plasma concentrations within 2 minutes followed by a rapid decline, and these plasma levels were significantly correlated with participant- and monitor-rated drug effects—this is the first human study to demonstrate a direct pharmacokinetic–effect relationship. Prolactin rose from 5 minutes and peaked at 15 minutes while cortisol responses were inconsistent, and the results confirm the efficacy of the vapour inhalation technique.

Published: February 15, 2016
Journal: Journal of Psychopharmacology
Authors: Johnson, M. W., Maclean, K. A., Caspers, M. J., Prisinzano, T. E., Griffiths, R. R.

Open Accessindividual

Salvinorin-A induces intense dissociative effects, blocking external sensory perception and modulating interoception and sense of body ownership in humans

This double-blind, randomised placebo-controlled, within-subjects study (n=8) investigated the effects of vaporized salvinorin-A (0.25, 0.50, & 1 mg) on interoception and the sense of body-ownership in healthy volunteers, who reported an increase of bodily sensations at moderate doses, and an almost complete loss of body ownership and out-of-body experiences at the highest. These effects were rapid and intense but short-lived and included perceptual modifications in the visual domain and commonly entailed auditory hallucinations that are not typical for serotonergic hallucinogens by contrast. This implicates that the Kappa opioid system plays a significant role in the regulation of sensory perception, interoception, and the sense of body ownership.

Published: June 5, 2015
Journal: International Journal of Neuropsychopharmacology
Authors: Maqueda, A. E., Valle, M., Addy, P. H., Puntes, M., Coimbra, J., Garrido, M., Claramunt, J., Barker, S., Johnson, M. W., Riba, J., Gonzales, M.

Open Accessindividual

Dose-related Behavioral, Subjective, Endocrine and Psychophysiological Effects Of the Kappa Opioid Agonist Salvinorin A in Humans

This double-blind, randomised controlled trial (n=10) assessed the behavioural, subjective, cognitive, psychophysiological and endocrine effects of Salvia divinorum (0, 8 and 12 mg) in healthy participants. Salvia produced psychotomimetic effects and perceptual alterations, including dissociative and somaesthetic effects, increased plasma cortisol and prolactin and reduced resting EEG spectral power, but did not produce euphoria, cognitive deficits or changes in vital signs. Overall, Salvia was well tolerated.

Published: November 1, 2012
Journal: Biological Psychiatry
Authors: Ranganathan, M., Schnakenberg, A., Skosnik, P. D., Cohen, B., Pittman, B. P., Sewell, R. A., D’Souza, D. C.

Open Accessindividual

Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum

This double-blind, placebo-controlled study (n=4) documents the subjective effects of salvinorin A (26mg up to 1.47g). Dose-related increases were observed in measures of mystical-type experience and subjective effects associated with classic serotonergic (5-HT2A) hallucinogens, with recurring themes such as revisiting childhood memories, cartoon-like imagery, and contact with entities.

Published: May 1, 2011
Journal: Drug and Alcohol Dependence
Authors: Johnson, M. W., Maclean, K. A., Reissig, C. J., Prisinzano, T. E., Griffiths, R. R.

Clinical Trials

0 trials

No clinical trials have been tagged with both Salvia Divinorum and Healthy Volunteers yet.

Trials are continuously being added as new studies are registered.

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Salvia Divinorum for Healthy Volunteers